T cell exclusion, immune privilege, and the tumor microenvironment
Explore this paper's citation graph
Summary
Evidence is reviewed that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells, and overcoming this T cell checkpoint may enable optimal immunotherapy.
- Type
- review
- Published
- 2015-04-03
- Cited by
- 2,217
- References
- 83
- OpenAlex
- https://openalex.org/W2060469376
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11603692
Keywords
Cytotoxic T cell, Immune system, Cancer immunotherapy, Tumor microenvironment, Cancer cell
References
- CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy.
- Active movement of T cells away from a chemokine
- Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.
- CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.
- Targeting TNF-α to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy
- Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis
- MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
- An inherently bi-functional subset of Foxp3+ T helper cells is controlled by the transcription factor Eos
- Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen Presenting Cells, Critical for T cell Immunity
- Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation.
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression
- Tumor Endothelium FasL Establishes a Selective Immune Barrier Promoting Tolerance in Tumors
- Adoptive cell transfer as personalized immunotherapy for human cancer
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models
- Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
- A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.
- Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones.
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- B cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas
- CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells
Cited by
- Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment
- Immunoengineering through cancer vaccines – A personalized and multi‐step vaccine approach towards precise cancer immunity
- CMTM 6 promotes the development of thyroid cancer by inhibiting NIS activity through activating the MAPK signaling pathway
- The prognostic value of plasma soluble CD40 ligand levels in patients with nasopharyngeal carcinoma.
- More than a scaffold: Stromal modulation of tumor immunity.
- Suppression of T cell responses in the tumor microenvironment.
- Prognostic Role of Tumor-Infiltrating Lymphocytes in Lung Cancer: a Meta-Analysis
- Role of Local Radiation Therapy in Cancer Immunotherapy.
- T cell metabolic reprogramming and plasticity
- Understanding high endothelial venules: Lessons for cancer immunology
- Molecular Pathways: Targeting the CXCR4–CXCL12 Axis—Untapped Potential in the Tumor Microenvironment
- Mesenchymal stromal cells inhibit murine syngeneic anti-tumor immune responses by attenuating inflammation and reorganizing the tumor microenvironment
- CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma?
- Establishing the pig as a large animal model for vaccine development against human cancer
- Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
- Real-Time Imaging of Resident T Cells in Human Lung and Ovarian Carcinomas Reveals How Different Tumor Microenvironments Control T Lymphocyte Migration
- Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy
- Glutathione-degradable drug-loaded nanogel effectively and securely suppresses hepatoma in mouse model
- Vaccines for Tumours: Melanoma
- Gastric cancer: The times they are a-changin'.
Related papers
- Role of the tumor immune microenvironment in tumor immunotherapy
- Immunotherapy and tumor microenvironment
- Present and future of cancer immunotherapy: A tumor microenvironmental perspective.
- Radiotherapy-induced tumor physical microenvironment remodeling to overcome immunotherapy resistance1.
- Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications
- Verification of Genetic Differences and Immune Cell Infiltration Subtypes in Neuroblastoma Tumor Microenvironment for Immunotherapy
- Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators
- B7-H3/CD276: An Emerging Cancer Immunotherapy
- Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy.
- pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review