Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
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Summary
A loss-of-function allele of the gene coding for formyl peptide receptor 1 (FPR1) was identified that was associated with poor metastasis-free and overall survival in breast and colorectal cancer patients receiving adjuvant chemotherapy.
- Type
- article
- Published
- 2015-11-20
- Cited by
- 429
- References
- 47
- OpenAlex
- https://openalex.org/W1911271782
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206641844
Keywords
Immunity, Receptor, Peptide, Chemistry, Chemotherapy
References
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- The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis
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- FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages
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- Trial watch
- Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance.
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- Platinum-Based Nanovectors Engineered with Immuno-Modulating Adjuvant for Inhibiting Tumor growth and Promoting Immunity
- Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
- Crizotinib-induced immunogenic cell death in non-small cell lung cancer
- Trial watch: IDO inhibitors in cancer therapy
- Getting Tumor Dendritic Cells to Engage the Dead.
- STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapy.
- Enhancing T cell therapy by overcoming the immunosuppressive tumor microenvironment.
- Microfluidics: A new tool for modeling cancer-immune interactions
- Therapy-induced microenvironmental changes in cancer
- The oncolytic peptide LTX-315 triggers immunogenic cell death
- PGE2 induced in and released by dying cells functions as an inhibitory DAMP
- The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer
- Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate
- Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1
- Microfluidics: A New Tool for Modeling Cancer-Immune
- The oncolytic peptide LTX-315 overcomes resistance of cancers to immunotherapy with CTLA4 checkpoint blockade
- Damage-associated molecular patterns in cancer: A double-edged sword
- Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria.
- Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation
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