Guidance of cell migration by the Drosophila PDGF/VEGF receptor.

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Summary

It is demonstrated that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte, and evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal is presented.

Type
article
Published
2001-10-05
Cited by
478
References
55
Access
Open access

Keywords

Biology, Platelet-derived growth factor receptor, Cell biology, Receptor tyrosine kinase, Cell migration

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