Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.
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Summary
Results suggest that Mbc is a specific upstream regulator of Rac activity that mediates several morphogenetic processes in Drosophila embryogenesis.
- Type
- article
- Published
- 1998-11-01
- Cited by
- 220
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977706313
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13027140
Keywords
Biology, Cell biology, Myogenesis, CDC42, Rac GTP-Binding Proteins
References
- Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes.
- The Embryonic Development of Drosophila melanogaster
- Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
- CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
- Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.
- Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS
- Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade.
- Cell fate in the Drosophila ommatidium.
- A brain serine/threonine protein kinase activated by Cdc42 and Rac1
- Dbl family proteins.
- The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation.
- Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase*
- Role of a new Rho family member in cell migration and axon guidance in C. elegans.
- The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.
- Effects of cytochalasin B on muscle cells in tissue culture.
- Rho GTPases and signaling networks.
- The role of RhoA in tissue polarity and Frizzled signalling
- Rho GTPases and the actin cytoskeleton.
- The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization
- DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane
Cited by
- Programmed Cell Death in C. elegans
- The Rho family of small GTPases: crucial regulators of skeletal myogenesis
- Genetic Control of Development of Malpighian Tubules in Drosophila melanogaster
- Myoblast fusion in Drosophila.
- Investigating the function of the Receptor Tyrosine Kinase ALK during Drosophila melanogaster development
- Phagocytosis of apoptotic cells in mammals, caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequences.
- Dock180/Elmo proteins are critical regulators of phagocytosis, macropinocytosis and chemotaxis in Dictyostelium
- Exploring Rac GTPase regulation : the molecular mechanisms governing the DOCK180 and ELMO interaction and the role of this complex in Rac-mediated cell migration
- Étude sur les fonctions in vivo des GEFs DOCK chez les mammifères
- In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains.
- The genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster.
- Ferlin proteins in myoblast fusion and muscle growth
- Signal transduction mechanisms in commissural axon guidance: The role of intracellular tyrosine kinases in Netrin-DCC/frazzled axon attraction
- Studying fibroblast growth factor (FGF) mediated cell migration in "Drosophila" larval air sacs
- CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
- Cell and molecular biology of myoblast fusion.
- Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
- Evidence for a Conserved Role for CrkII and Rac in Engulfment of Apoptotic Cells*
- Rho GTPases and cell migration.
- An Analysis of Rho-PKN Signaling in Prostate Cancer Using Drosophila Genetics
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