Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation
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Summary
Results indicate that PTPN3 may act as a tumor suppressor in lung cancer through its modulation of EGFR signaling.
- Type
- article
- Published
- 2014-09-29
- Cited by
- 47
- References
- 60
- OpenAlex
- https://openalex.org/W25263444
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19884918
Keywords
Energy (signal processing), Environmental science, Computer science, Mathematics, Statistics
References
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- EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming
- On the move: endocytic trafficking in cell migration
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- Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report
- A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes
- Regulation of pancreatic β-cell death and cancer cell migration by TPRM2 channels
- Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer
- Lung cancer in patients with idiopathic pulmonary fibrosis.
- Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification.
- Clearance of a persistent picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses
- Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization
- NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest
- PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study
- High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma
- The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene
- Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein
- PTPN3 acts as a tumor suppressor and boosts TGF‐β signaling independent of its phosphatase activity
- PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization
- Cytoskeleton protein 4.1R suppresses murine keratinocyte cell hyperproliferation via activating the Akt/ERK pathway in an EGFR-dependent manner.
- PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor