Histone H3 Lysine 36 Dimethylation (H3K36me2) Is Sufficient to Recruit the Rpd3s Histone Deacetylase Complex and to Repress Spurious Transcription*
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Summary
Using methyl-lysine analog technology, it is demonstrated that the histone deacetylase complex, Rpd3S, can distinguish the nucleosomes methylated to different extents and that K36me2 is sufficient to target RPD3S in vitro.
- Type
- article
- Published
- 2009-03-20
- Cited by
- 159
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975794113
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34939809
Keywords
Histone H3, Histone deacetylase 2, Histone, Chemistry, Histone deacetylase
References
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- Ssn6-Tup1 Regulates RNR3 by Positioning Nucleosomes and Affecting the Chromatin Structure at the Upstream Repression Sequence*
- Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.
- Plant virus expression systems for transient production of recombinant allergens in Nicotiana benthamiana.
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- Heterochromatin protein 1: don't judge the book by its cover!
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- Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.
- Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
- Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
- The role of chromatin during transcription.
Cited by
- Investigating the combined burden of transcription and quality control errors in yeast
- A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins.
- Influence of CpG islands on chromatin structure
- Role of CpG island methylation and MBD2 in immune cell gene regulation
- The roles of the Saccharomyces cerevisiae Paf1 complex in regulating transcriptional repression
- UNCOVERING THE MECHANISM OF CHROMATIN ASSOCIATION OF THE PAF1 TRANSCRIPTION ELONGATION COMPLEX
- Understanding the Role of Lysine-Specific Demethylase 1 in Embryonic Gene Regulation
- Étude de la variante d’histone H2A.Z et du cycle de phosphorylation de l’ARN polymérase II chez Saccharomyces cerevisiae
- Set2 mediated H3 lysine 36 methylation: Regulation of transcription elongation and implications in organismal development
- Award Number: W81XWH-11-1-0304 TITLE: Avoiding microRNA Function Through Alternative Polyadenylation in Prostate Cancer
- Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns*
- Structure and function of active chromatin and DNase I hypersensitive sites
- Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex
- Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes
- Chemical Approaches for Studying Histone Modifications*
- Top‐down analysis of recombinant histone H3 and its methylated analogs by ESI/FT‐ICR mass spectrometry
- Understanding the language of Lys36 methylation at histone H3
- JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation
- Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island
- Structure of the 30-kDa Sin3-associated Protein (SAP30) in Complex with the Mammalian Sin3A Corepressor and Its Role in Nucleic Acid Binding*
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