Histone deacetylase inhibitors as new cancer drugs
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Summary
This review summarizes the characteristics of a variety of inhibitors of histone deacetylases and their effects on transformed cells in culture and tumor growth in animal models.
- Type
- review
- Published
- 2001-11-01
- Cited by
- 560
- References
- 53
- OpenAlex
- https://openalex.org/W2070437897
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10246276
Keywords
Histone deacetylase 5, Histone deacetylase, HDAC11, Histone deacetylase 2, HDAC10
References
- Multiple N-CoR Complexes Contain Distinct Histone Deacetylases*
- Histone acetylases—versatile players
- DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
- Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
- DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
- Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
- Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia.
- Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment
- MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells.
- Molecular targets for breast cancer therapy and prevention
- The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid.
- Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.
- Effect of trichostatin A on cell growth and expression of cell cycle‐ and apoptosis‐related molecules in human gastric and oral carcinoma cell lines
- The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
- Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.
- Acetylation of TAFI68, a subunit of TIF‐IB/SL1, activates RNA polymerase I transcription
- The human histone deacetylase family.
- The language of covalent histone modifications
- CoREST is an integral component of the CoREST- human histone deacetylase complex.
- Butyrate as a model for "gene-regulating chemoprevention and chemotherapy.".
Cited by
- HLA-G gene repression is reversed by demethylation
- Plasma and cerebrospinal fluid pharmacokinetics of depsipeptide (FR901228) in nonhuman primates
- Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting.
- Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells.
- Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity
- Development of strategies for vascular damage repair in Pulmonary Arterial Hypertension
- Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors.
- Valproate–doxorubicin: promising therapy for progressing mesothelioma. A phase II study
- Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1
- Etude des mécanismes épigénétiques impliqués dans la kystogénèse chez le pathogène humain Toxoplasma gondii
- Modulation of Folate Receptor Beta for Drug Targeting in Acute Myelogenous Leukemia
- Novel Agents for Chemoprevention, Screening Methods, and Sampling Issues
- Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells.
- A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation
- MANIPULATION OF REGULATORY MYELOID CELL DIFFERENTIATION AND FUNCTION AND ITS THERAPEUTIC IMPLICATIONS
- Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis.
- Use of Polyamine Derivatives as Selective Histone Deacetylase Inhibitors
- Cancer-testis antigen expression in bladder cancer.
- Small molecule modulators in epigenetics: implications in gene expression and therapeutics.
- Conception et synthese de nouvelles sondes ciblees pour l'imagerie moleculaire
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