Update of histone deacetylase inhibitors

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Summary

Histone deacetylase(HDAC)inhibitors contain a functional group that mimics lysine side chain that interacts with the critical HDAC Zinc atom to modulate the gene transcription and expression, inhibit cell proliferation, stimulate cell differentiation, and provocate cell apoptosis.

Type
article
Published
2008-01-01
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Keywords

Histone deacetylase, Histone deacetylase 5, HDAC11, Acetylation, Histone deacetylase 2

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