Mitochondria as the central control point of apoptosis.

Keywords

Biology, Bcl-2 family, Mitochondrion, Apoptosis, Cytochrome c

References

• Chemical and physical fixation of isolated mitochondria in low-energy and high-energy states.Irwin Weiser — 1968
• The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariantJoshua C. Goldstein, Nigel J. Waterhouse, Phillipe Juin — 2000
• Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?Matthew G. Vander Heiden, Craig B. Thompson — 1999
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosisXiao‐Ming Yin, Kun Wang, Atan Gross — 1999
• Injected cytochrome c induces apoptosisBoris Zhivotovsky, Sten Orrenius, Odd Terje Brustugun — 1998
• How BAD phosphorylation is good for survivalJulian Downward — 1999
• Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDACShigeomi Shimizu, Masashi Narita, Yoshihide Tsujimoto — 1999
• Bcl-2 prolongs cell survival after Bax-induced release of cytochrome cThierry Rossé, Reynald Olivier, Laurent Monney — 1998
• X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell deathSteven W. Muchmore, Michael Sattler, Heng Liang — 1996
• [Mitochondrial control of apoptosis].Guido Kroemer, Naoufal Zamzami, Santos A. Susín — 2001
• Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID*Sharon L. Schendel, Rustam Azimov, Krzysztof Pawłowski — 1999
• The mitochondrial permeability transition pore and its role in cell death.Martin Crompton — 1999
• Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.Matthew G. Vander Heiden, Navdeep S. Chandel, Edward K. Williamson — 1997
• Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedJie Yang, Xuesong Liu, Kapil N. Bhalla — 1997
• The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.Hamsa Puthalakath, David C.S. Huang, LORRAINE A. O'REILLY — 1999
• Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.Masashi Narita, Shigeomi Shimizu, Toshinori Ito — 1998
• Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell LineMariangela Mancini, Benjamin O. Anderson, Elizabeth Caldwell — 1997
• Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations.Gorka Basáñez, Amotz Nechushtan, O. Drozhinin — 1999
• Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.Dorothy Newmeyer — 1994
• Bcl-2 family proteins as ion-channelsSharon L. Schendel, M Montal, John C. Reed — 1998

Cited by

• Study of intracellular signaling pathways triggered by natural antioxidants in human endothelial cellsCossu, Annalisa — 2012
• Characterization of the Role of Mitochondrial Function During Tumor Development and Muscle WastingXiao Wang — 2012
• Apoptotic Cleavage of Cytoplasmic Dynein Intermediate Chain and P150GluedStops Dynein-Dependent Membrane MotilityPablo García Dussán — 2001
• Electrical stimulation of cerebellar fastigial nucleus protects rat brain, in vitro, from staurosporine‐induced apoptosisHugo Alfonso Hernández Escolar, Jhon Alexander Méndez Sayago, Nubia Stella Carreño Amaya — 2001
• Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodiesPi-chen Liu — 2001
• Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes.Dong-Hee Choi, Dong Hoon Kim, Yun-Gyu Park — 2002
• Glutathione disulfide induces apoptosis in U937 cells by a redox‐mediated p38 mitogen‐activated protein kinase pathwayGiuseppe Filomeni, Giuseppe Rotilio, Maria Rosa Ciriolo — 2003
• H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMAAndrea Cortellessa — 2003
• Significance of endothelial cell survival programs for renal transplantation.Valerie Laget — 2003
• Respiratory inhibition of isolated mammalian mitochondria by salivary antifungal peptide histatin-5.秀也 高橋, 肇 中村, 邦彦 白木 — 2003
• Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide.Christina Erna Widiastuti — 2003
• Astrocyte apoptosis: implications for neuroprotection.Norin Chai — 2004
• Bax Does Not Directly Participate in the Ca2+-induced Permeability Transition of Isolated Mitochondria*Umberto De Marchi, Silvia Campello, Ildikò Szabó — 2004
• Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60.Juan Manuel González Sáez — 2004
• Genistein Induces Apoptosis in T Lymphoma Cells via Mitochondrial DamageJ.N. Reyes — 2005
• The Effect of Mild and Severe Hypoxia on Rat Cortical Synaptosomes理 土田, 亮子 氏家, 聡 末廣 — 2005
• The cell cycle inhibitor p57Kip2 promotes cell death via the mitochondrial apoptotic pathway静一 佐藤, 忠輔 武田, 敏昭 田崎 — 2007
• Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repairZhiliang Wu, Ljiljana Sofronić‐Milosavljević, Isao Nagano — 2008
• Formosanin C‐induced apoptosis requires activation of caspase‐2 and change of mitochondrial membrane potentialЛюбов Евгений Борисович — 2009
• Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL.Emily Goodhue — 2009

Related papers

• Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?Yoshihide Tsujimoto — 1998
• Injected cytochrome c induces apoptosisBoris Zhivotovsky, Sten Orrenius, Odd Terje Brustugun — 1998
• The apoptosome: physiological, developmental, and pathological modes of regulation.Zachary T. Schafer, Sally Kornbluth — 2006
• Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and BakPooja Patel, Arielys Mendoza, Dexter Robichaux — 2021
• Essential role of voltage —dependent anion channel （VDAC） in mitochondrial permeability transition and cytochrome C release induced by arsenic trioxideYanhuazheng, Rongshi — 2002
• Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transitionJared L. Scarlett, Michael P. Murphy — 1997
• Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ IonsRobert Eskes, Bruno Antonsson, Astrid Osen‐Sand — 1998
• VDAC regulation by the Bcl-2 family of proteinsYoshihide Tsujimoto, Shigeomi Shimizu — 2000
• Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?Laurent M. Dejean, Sonia Martinez‐Caballero, Kathleen W. Kinnally — 2006
• Relationship of Mitochondrial Permeability Transition with Cell ApoptosisYuehui Ma — 2008