The IKK complex contributes to the induction of autophagy
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Summary
It is shown that multiple inducers of autophagy, including nutrient depletion, trigger the activation of the IKK (IκB kinase) complex that is best known for its essential role in theactivation of the transcription factor NF‐κB by stress.
- Type
- article
- Published
- 2010-02-03
- Cited by
- 296
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974251566
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24673294
Keywords
Autophagy, Biology, IκB kinase, Cell biology, Transcription factor
References
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- The p53-regulated Sestrin gene products inhibit mTOR signaling
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
- Cell biology: Regulated self-cannibalism
- Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
- The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.
- Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.
- p53 stabilization is decreased upon NFκB activation
- Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation.
- Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
- The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
- Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor.
- Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
- Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP
- Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.
Cited by
- Vitamin D, Vitamin D Receptor, and Macroautophagy in Inflammation and Infection
- Crosstalk Between Apoptosis and Autophagy : BH3 Mimetics Activate Multiple Pro-Autophagic Pathways
- Drug Screening for Autophagy Inhibitors Based on the Dissociation of Beclin1-Bcl2 Complex Using BiFC Technique and Mechanism of Eugenol on Anti-Influenza A Virus Activity
- Human T-Cell Leukemia Virus Type 1 Tax-Deregulated Autophagy Pathway and c-FLIP Expression Contribute to Resistance against Death Receptor-Mediated Apoptosis
- TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
- Growth inhibitory effect of paratocarpin E, a prenylated chalcone isolated from Euphorbia humifusa Wild., by induction of autophagy and apoptosis in human breast cancer cells.
- Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
- Investigating the role of reactive oxygen species in regulating autophagy.
- Characterization of the mechanisms underlying alterations in macroautophagy and survival signalling in Huntington’s disease
- Etude de la régulation de l’autophagie au cours de la différenciation des cellules de leucémie aiguë promyélocytaire : rôles dans la survie et la différenciation cellulaire
- Membrane-remodeling by SNX18 in endosomal transport and autophagy
- TRAF6 signaling in skeletal muscle atrophy and regeneration
- Cellular response to stress and DNA damage : the role of Sirtuins in the regulation of autophagy
- Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells
- Le rôle de l’ubiquitination et des endomembranes dans l’activation du facteur de transcription NF-κB
- The Senescent Cell Induced Bystander Effect
- AKT mediated glycolytic shift regulates autophagy in classically activated macrophages.
- Autophagy in Toxicology: Self-consumption in times of stress and plenty
- Melatonin modulates autophagy through a redox‐mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity
- Targeting the Prostate Cancer Microenvironment to Improve Therapeutic Outcomes
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