Drug Screening for Autophagy Inhibitors Based on the Dissociation of Beclin1-Bcl2 Complex Using BiFC Technique and Mechanism of Eugenol on Anti-Influenza A Virus Activity
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Summary
A drug screening model based on the inhibition of the dissociation of Beclin1-Bcl2 heterodimer, an important negative regulator of autophagy, using bimolecular fluorescence complementation (BiFC) technique is established and eugenol is found as a promising inhibitor for Autophagy and IAV infection.
- Type
- article
- Published
- 2013-04-16
- Cited by
- 113
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W23613775
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9153944
Keywords
Antihypertensive drug, Outcome (game theory), Drug, Medicine, Business
References
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Cited by
- The interaction of eugenol with cell membrane models at the air-water interface is modulated by the lipid monolayer composition.
- Sensing of biomolecular interactions using fluorescence complementing systems in living cells.
- Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni
- New Eugenol Glucoside‐based Derivative Shows Fungistatic and Fungicidal Activity against Opportunistic Candida glabrata
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- PI3K/Akt Signaling Pathway Modulates Influenza Virus Induced Mouse Alveolar Macrophage Polarization to M1/M2b
- Inhibition of Tanshinone IIA, Salvianolic Acid A and Salvianolic Acid B on Areca Nut Extract-Induced Oral Submucous Fibrosis in Vitro
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- Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia
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