Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2*
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Summary
The demonstration that Tie2 as well as angiopoietin-1 are expressed in normal human arteries and veins suggests that the role of angioietin/Tie2 may extend beyond embryonic angiogenesis to maintaining integrity of the adult vasculature.
- Type
- article
- Published
- 1998-07-17
- Cited by
- 453
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974045062
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41910405
Keywords
Angiopoietin receptor, Angiopoietin, Angiogenesis, Cell biology, Receptor tyrosine kinase
References
- A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration.
- tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.
- Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization.
- The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.
- A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.
- Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.
- Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.
- Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.
- Differentiation of endothelium
- Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage.
- Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
- Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development
- Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals.
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
- Growth factor signaling by receptor tyrosine kinases.
- Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
- Angiogenesis in cancer, vascular, rheumatoid and other disease
- Reciprocal relation between VEGF and NO in the regulation of endothelial integrity
Cited by
- Angiopoietin‐1 is an apoptosis survival factor for endothelial cells
- Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma
- Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2.
- Potential role of the angiopoietin/tie2 system in ischemia-induced retinal neovascularization.
- Angiogenesis of the heart
- Angiopoietin‐1 inhibits endothelial permeability, neutrophil adherence and IL‐8 production
- The Role of the Angiopoietins in Tumour Angiogenesis
- Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin, hemeoxygenase and vascular endothelial growth factor.
- ICAM-1 depletion does not alter retinal vascular development in a model of oxygen-mediated neovascularization.
- Thermostable DNA Polymerase from a Viral Metagenome Is a Potent RT-PCR Enzyme
- Serum biomarkers of papillary thyroid cancer
- Vasculogenesis and Angiogenesis as Mechanisms of Vascular Network Formation, Growth and Remodeling
- Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes.
- Production and characterization of a Tie2 agonist monoclonal antibody
- Tek/Tie2 Signaling: New and Old Partners
- Controlled release of angiogenic growth factors from poly(lactic -co -glycolic acid) implants for therapeutic angiogenesis
- Expression and significance of angiopoietin-2 in gastric cancer.
- Angiogenesis in rheumatoid arthritis.
- Angiogenesis and Vasculogenesis in Treatment of Cardiovascular Disease
- Abl Family Kinases Regulate Endothelial Function
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