Position effects in mice carrying a lacZ transgene in cis with the beta-globin LCR can be explained by a graded model.

Keywords

Biology, Transgene, Locus control region, Globin, Molecular biology

References

• Human globin locus activation region (LAR): role in temporal control.育子 本田, まち子 猿賀, 善宗 小林 — 1990
• The beta‐globin locus control region enhances transcription of but does not confer position‐independent expression onto the lacZ gene in transgenic mice.Louis-Georges Guy, Rashmi Kothary, Yves DeRepentigny — 1996
• Separable cis‐acting control elements for expression of the white gene of Drosophila.Robert Levis, Tulle Hazelrigg, Gerald M. Rubin — 1985
• Definition of the minimal requirements within the human beta‐globin gene and the dominant control region for high level expression.Phil Collis, Michael Antoniou, Frank Grosveld — 1990
• Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence elementQ Li, J A Stamatoyannopoulos — 1994
• Germ-line transformation of mice.Richard D. Palmiter, Ralph L. Brinster — 1986
• Variegated gene expression in mice.Kenneth W Dobie — 1997
• Variegated expression of a globin transgene correlates with chromatin accessibility but not methylation status.David Garrick, Heidi G. Sutherland, Gerry Robertson — 1996
• Position effect and related phenomena.Steven Henikoff — 1992
• Position effect variegation at fission yeast centromeres.Robin C. Allshire, Jean‐Paul Javerzat, Nicola J. Redhead — 1994
• Formation of stable transcription complexes as assayed by analysis of individual templates.H Weintraub — 1988
• Simian virus 40 enhancer increases RNA polymerase density within the linked geneFrank Weber, Walter Schaffner — 1985
• DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations.Cees Waalwijk, Richard A. Flavell — 1978
• Position-dependent variegation of globin transgene expression in mice.Gerry Robertson, David Garrick, W Wu — 1995
• The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants.Patrice Moreau, René Hen, Bohdan Wasylyk — 1981
• Chromatin as an essential part of the transcriptional mechanimGary Felsenfeld — 1992
• Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNARichard Treisman, Tom Maniatis — 1985
• What does the locus control region control?Elliot Epner, Chul Geun Kim, Mark Groudine — 1992
• Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.Peter Fraser, S. Pruzina, Michael Antoniou — 1993
• Human gamma- to beta-globin gene switching in transgenic mice.Richard R. Behringer, Thomas M. Ryan, Richard D. Palmiter — 1990

Cited by

• alpha-thalassemia resulting from a negative chromosomal position effect.Virginia Barbour, Cristina Tufarelli, Jacqueline A. Sharpe — 2000
• Analysis of Cell-Specificity and Variegation of Transgene Expression Driven by Salmon Prolactin Promoter in Stable Lines of Transgenic Rainbow TroutSvetlana Uzbekova, C. Amoros, Chantale Cauty — 2003
• Tetracycline-Inducible System for Regulation of Skeletal Muscle-Specific Gene Expression in Transgenic MiceMischala A. Grill, Mark Bales, Amber N. Fought — 2003
• Distant upstream regulatory domains direct high levels of beta -myosin heavy chain gene expression in differentiated embryonic stem cells.Kathy L. Schreiber, Angelino Calderone, Hansjörg Rindt — 2000
• Going the distance: a current view of enhancer action.Elizabeth M. Blackwood, James T. Kadonaga — 1998
• The tkNeo gene, but not the pgkPuro gene, can influence the ability of the beta-globin LCR to enhance and confer position-independent expression onto the beta-globin gene.Qi Mei, Rashmi Kothary, Lee Wall — 2000
• Increasing D4Z4 repeat copy number compromises C2C12 myoblast differentiationDarren J. Yip, David J. Picketts — 2003
• IGF-I causes an ultrasensitive reduction in GH mRNA levels via an extracellular mechanism involving IGF binding proteins.Ty C. Voss, Maxfield P. Flynn, David L. Hurley — 2001
• Transgenic Analysis of the Stem Cell Leukemia +19 Stem Cell Enhancer in Adult and Embryonic Hematopoietic and Endothelial CellsLev Silberstein, María J. Sánchez, Merav Socolovsky — 2005
• Mosaic expression of LacZ reporter gene controlled by 5′-regulatory sequences of alpha-S1-Casein gene in transgenic miceIrina Serova, Л. Е. Андреева, Н. В. Хайдарова — 2009
• Capn8 promoter directs the expression of Cre recombinase in gastric pit cells of transgenic miceZengming Zhao, Yanxun Sun, Ning Hou — 2009
• Factors Affecting de Novo Methylation of Foreign DNA in Mouse Embryonic Stem Cells*Jennifer Hertz, Gudrun Schell, Walter Doerfler — 1999
• Locus control regions and epigenetic chromatin modifiers.Richard Festenstein, Dimitris Kioussis — 2000
• Transgenic Cre expression mice for generation of erythroid‐specific gene alterationsKenneth R. Peterson, Halyna Fedosyuk, Lesya Zelenchuk — 2004
• Artificial chromosome-based transgenes in the study of genome functionJason D. Heaney, Sarah K. Bronson — 2006
• Relative transgene expression frequencies in homozygous versus hemizygous transgenic miceSu-Ping Chang, Margaret L. Opsahl, Bruce Whitelaw — 2013
• The specificity of the myelin basic protein gene promoter studied in transgenic mice.Aruna Asipu, Andrew L. Mellor, G. Eric Blair — 2001
• Generation dependent reduction of tTA expression in double transgenic NZL‐2/tTACMV miceLev M. Fedorov, Oleg Yu. Tyrsin, Olena Sakk — 2001
• Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.Timothy A. Graubert, Bruce A. Hug, Robin L. Wesselschmidt — 1998
• Intestinal Expression of the Calbindin-D9K Gene in Transgenic MiceSabine Colnot, Béatrice Romagnolo, Mireille Lambert — 1998

Related papers

• Construction of a RFP-lacZα bicistronic reporter system and its application in lead biosensingChang-ye Hui, Yan Guo, Lisa Liu — 2020
• Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice.Raouf Alami — 2000
• Globin Gene SwitchingTohru Ikuta, Thalia Papayannopoulou, George Stamatoyannopoulos — 1996
• Locus control region activity by 5′HS3 requires a functional interaction with β-globin gene regulatory elements: expression of novel β/γ-globin hybrid transgenesJoel E. Rubin, Peter Pasceri, Xiumei Wu — 2000
• Locus control region activity by 5′HS3 requires a functional interaction with β-globin gene regulatory elements: expression of novel β/γ-globin hybrid transgenesJoel E. Rubin, Peter Pasceri, Xiumei Wu — 2000
• Improved Monitoring of Low-Level Transcription in Escherichia coli by a β-Galactosidase α-Complementation SystemYan Guo, Chang-ye Hui, Lisa Liu — 2019
• An Improved Staining Method for Low Signal LacZ Reporter Detection in Mouse Embryos.Xiaopeng Shen, Feng Xu, Shen Wu — 2019
• The position of integration affects expression of the A gamma-globin-encoding gene linked to HS3 in transgenic mice.Patrick A. Navas, B Josephson, T Furukawa — 1995
• Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high‐level expression of a human β‐globin transgene in a centromeric regionSung‐Hae Kang, Padraic P. Levings, Félicie F. Andersen — 2004