The beta‐globin locus control region enhances transcription of but does not confer position‐independent expression onto the lacZ gene in transgenic mice.

Keywords

Biology, Locus control region, Gene, Transcription (linguistics), Transgene

References

• The Molecular Basis of Blood DiseasesI. R. Peake — 1988
• Hemoglobin switchingArthur W. Nienhuis, George Stamatoyannopoulos — 1978

Cited by

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• Spatial organization of gene expression: the active chromatin hubWouter de Laat, Frank Grosveld — 2003
• Beta-globin regulation and long-range interactions.Robert‐Jan Palstra, Wouter de Laat, Frank Grosveld — 2008
• Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment.Sarah Ogilvy, Donald Metcalf, Leonie Gibson — 1999
• Frataxin overexpressing miceCarlos J. Miranda, Manuela M Santos, Keiichi Ohshima — 2004
• Human HMG box transcription factor HBP1: a role in hCD2 LCR functionTalgat Zhuma, Richard Tyrrell, Belaïd Sekkali — 1999
• The tkNeo gene, but not the pgkPuro gene, can influence the ability of the beta-globin LCR to enhance and confer position-independent expression onto the beta-globin gene.Qi Mei, Rashmi Kothary, Lee Wall — 2000
• Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesisHolger Hiemisch, Günther Schütz, Klaus H. Kaestner — 1997
• Position effects in mice carrying a lacZ transgene in cis with the beta-globin LCR can be explained by a graded model.Louis-Georges Guy, Rashmi Kothary, Lee Wall — 1997
• Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?Constanze Bonifer — 2000
• Chromosomal sequences flanking an efficiently expressed transgene dramatically enhance its expression.Anona Jane Cranston, Chen Dong, Jill Howcroft — 2001
• Mosaic expression of LacZ reporter gene controlled by 5′-regulatory sequences of alpha-S1-Casein gene in transgenic miceIrina Serova, Л. Е. Андреева, Н. В. Хайдарова — 2009
• Long-distance chromatin mechanisms controlling tissue-specific gene locus activation.Constanze Bonifer — 1999
• A Targeted Disruption of the Murine Complement Factor B Gene Resulting in Loss of Expression of Three Genes in Close Proximity, Factor B, C2, and D17H6S45 *Philip R. Taylor, Julian T. Nash, Efstathios Theodoridis — 1998
• Expression of a Human β-Globin Transgene in Mice with the CACC Motif and Upstream Sequences Deleted from the Promoter Still Depends on Erythroid Krüppel-like Factor*Louis-Georges Guy, Nathalie Delvoye, Lee Wall — 2000
• Locus control region activity by 5′HS3 requires a functional interaction with β-globin gene regulatory elements: expression of novel β/γ-globin hybrid transgenesJoel E. Rubin, Peter Pasceri, Xiumei Wu — 2000
• The design of a new mutation model for active genes: expression of the Escherichia coli lac operon in mammalian cells.Petra P. H. Van Sloun, P.H.M. Lohman, Harry Vrieling — 1997
• Human germline genetic modification: scientific and bioethical perspectives.Kevin R. Smith, Sarah Chan, John Harris — 2012
• Bin1 Src Homology 3 Domain Acts as a Scaffold for Myofiber Sarcomere Assembly*Pasan Fernando, Jacqueline S. Sandoz, Wen Ding — 2009
• Heme Oxygenase-1 Gene Enhancer Manifests Silencing Activity in a Chromatin Environment Prior to Oxidative StressYoshihiro Dohi, Jawed Alam, Masao Yoshizumi — 2006

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