NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease
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Summary
It is shown that cholesterol crystals activate the NLRP3 inflammasome in phagocytes in vitro in a process that involves phagolysosomal damage and that crystalline cholesterol acts as an endogenous danger signal and its deposition in arteries or elsewhere is an early cause rather than a late consequence of inflammation.
- Type
- article
- Published
- 2010-04-01
- Cited by
- 2,633
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972483153
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4423075
Keywords
Inflammasome, Inflammation, Cholesterol, LDL receptor, Chemistry
References
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Cited by
- Role of immune mediators in metabolic syndrome and atherosclerosis
- Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation.
- Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway
- Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
- The p50 Subunit of NF-κB Orchestrates Dendritic Cell Lifespan and Activation of Adaptive Immunity
- Cytokines and Immune Responses in Murine Atherosclerosis.
- Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
- Macrophages in Vascular Inflammation: Origins and Functions
- Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes.
- Nlrp3 Gene Expression in Circulating Leukocytes Declines During Healthy Aging
- The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes
- Pyroptosis versus necroptosis: similarities, differences, and crosstalk
- Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
- The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis
- Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
- Roles of Macrophage Mitochondrial Oxidative Stress and Mitochondrial Fission in Atherosclerosis
- Type 2 diabetes mellitus: a metabolic autoinflammatory disease.
- Inducible lysosome renitence in macrophages
- Increased Expression and Activation of Absent in Melanoma 2 Inflammasome Components in Lymphocytic Infiltrates of Abdominal Aortic Aneurysms
- Assessment and quantification of crystal-induced lysosomal damage.
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