Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.
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Summary
The endogenous apolipoprotein E (apoE) gene is inactivated by using gene targeting in mouse embryonic stem (ES) cells by using two targeting plasmids, both containing a neomycin-resistance gene that replaces a part of the apoE gene and disrupts its structure.
- Type
- article
- Published
- 1992-05-15
- Cited by
- 989
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W2062108627
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25390304
Keywords
Biology, Molecular biology, Electroporation, Gene targeting, Gene
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- Reduced progression of atherosclerosis in apolipoprotein E-deficient mice with phenylhydrazine-induced anemia.
- Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages
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- Reduced Atherosclerotic Lesion Size in P-Selectin Deficient Apolipoprotein E-Knockout Mice Fed a Chow but Not a Fat Diet
- Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis.
- Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice.
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- A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus
- Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy
- Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE-/- mice.
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