CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
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Summary
It is shown that oxidized LDL and amyloid-β trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6 that is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands.
- Type
- article
- Published
- 2009-12-27
- Cited by
- 1,537
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W2045772297
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16399118
Keywords
Inflammation, Scavenger receptor, TLR2, CD36, Toll-like receptor
References
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- Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients.
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- Toll-like receptor signalling
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- The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
- Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.
- CD36 is a sensor of diacylglycerides
Cited by
- Plasma Factors as Endogenous Agonists and Modulators of TLR4 Signaling in Microglia
- RAGE-mediated cell signaling.
- Intracellular and extracellular cytokine-like functions of prothymosin α: implications for the development of immunotherapies.
- Signaling through Toll‐like receptor 4 and mast cell‐dependent innate immunity responses
- Making a Difference: Monocyte Heterogeneity in Cardiovascular Disease
- Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders
- CEP Is An Important And Ubiquitous Oxidation Specific Epitope Recognized By Innate Pattern Recognition Receptors
- Microglia–blood vessel interactions: a double-edged sword in brain pathologies
- Association of Lyn kinase with membrane rafts determines its negative influence on LPS-induced signaling
- Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model
- The atheroprotective role of lipoxin A4 prevents oxLDL-induced apoptotic signaling in macrophages via JNK pathway.
- Potential Immunotargets for Alzheimer's Disease Treatment Strategies
- A fatal attraction: macrophage recruitment to the atherosclerotic plaque
- Regulation of Lipid Homeostasis, Inflammatory Signalling and Atherosclerosis by the Peroxisome Proliferator-Activated Receptor Delta
- Induction of innate immune responses by plant-derived procyanidins and polysaccharides
- Toll-Like Receptor 2 and Partner Receptors in Alzheimers Disease
- Investigating Gp96 Biology and its Macrophage-Intrinsic Role in Colitis-Associated Colon Tumorigenesis
- Residual Immune Dysregulation Syndrome in Treated HIV infection
- Nouveaux régulateurs de la signalisation TLR2-NF-kB
- P2X7 Activation of Non-Primed Myeloid Cells Promotes the Shedding of Stimulatory Materials Within Microvesicles
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