The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes
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Summary
Evidence from mouse models supports a model whereby ALRs are required for IFN-mediated host response to both exogenous and endogenous DNA and inflammasome-mediated upregulation of IL-1β and IL-18 production positively correlates with SLE disease severity.
- Type
- article
- Published
- 2018-05-28
- Cited by
- 51
- References
- 164
- Access
- Open access
- OpenAlex
- https://openalex.org/W29892303
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44084616
Keywords
Computer science
References
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- Structures of The HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of The AIM2 Inflammasome and IFI16 Receptor
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- Cutaneous lupus erythematosus: new insights into pathogenesis and therapeutic strategies
- The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer
- Current status of terpenoids as inflammasome inhibitors.
- PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells
- Primary immunodeficiencies in cytosolic pattern‐recognition receptor pathways: Toward host‐directed treatment strategies
- Pattern recognition receptor‐mediated inflammation in diabetic vascular complications
- AIM2 Inflammasome's First Decade of Discovery: Focus on Oral Diseases
- Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands.
- Immunostimulatory Endogenous Nucleic Acids Perpetuate Interface Dermatitis—Translation of Pathogenic Fundamentals Into an In Vitro Model
- Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes
- Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response
- Pattern recognition receptors in health and diseases
- Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
- Epigenetic and transcriptional regulation of innate immunity in cancer
- The Interplay between Viruses and Host DNA Sensors
- The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease
- Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases
- Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD
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