The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Explore this paper's citation graph
Summary
Akt is not only capable of activating prosynthetic pathways, as previously demonstrated, but is simultaneously and dominantly able to suppress catabolic pathways, allowing it to prevent glucocorticoid and denervation-induced muscle atrophy.
- Type
- article
- Published
- 2004-05-07
- Cited by
- 1,975
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1971857747
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24235559
Keywords
Protein kinase B, Biology, FOXO1, PI3K/AKT/mTOR pathway, Phosphorylation
References
- Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
- Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
- Ras is involved in nerve-activity-dependent regulation of muscle genes
- Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
- Direct control of the Forkhead transcription factor AFX by protein kinase B
- Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth.
- Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats.
- Protein turnover measured in vivo and in vitro in muscles undergoing compensatory growth and subsequent denervation atrophy.
- Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
- Glucocorticoids and muscle catabolism.
- FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts
- Glucocorticoids Induce Proteasome C3 Subunit Expression in L6 Muscle Cells by Opposing the Suppression of Its Transcription by NF-κB*
- Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle.
- Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
- Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures.
- What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?
- Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
- Control of Ser2448 Phosphorylation in the Mammalian Target of Rapamycin by Insulin and Skeletal Muscle Load*
- DEXAMETHASONE STIMULATES PROTEASOME- AND CALCIUM‐DEPENDENT PROTEOLYSIS IN CULTURED L6 MYOTUBES
- Forkhead transcription factors: key players in development and metabolism.
Cited by
- Insulin-Like Growth Factor-1 Physiology: Lessons from Mouse Models
- Cibles moléculaires de la myostatine impliquées dans l'hypertrophie musculaire chez la souris et le bovin
- Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity.
- New fundamental resistance exercise determinants of molecular and cellular muscle adaptations
- Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process.
- Short bouts of stretching increase myo‐D, myostatin and atrogin‐1 in rat soleus muscle
- Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle.
- The scientific rationale for optimizing nutritional support in cancer
- Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway.
- FOXO1 Regulates the Expression of 4E-BP1 and Inhibits mTOR Signaling in Mammalian Skeletal Muscle*
- GSK-3beta activity is increased in skeletal muscle after burn injury in rats.
- Geometric control of myogenic cell fate
- The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.
- Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: significant evidence for linkage at chromosome 14q24.3
- Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials
- Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages
- Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes.
- Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury
- Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model
- Regulation of muscle atrophy in aging and disease.
Related papers
- The poxvirus encoded ubiquitin ligase, p28, is regulated by proteasomal degradation and autoubiquitination.
- Ubiquitination and Degradation of Mutant p53
- Promiscuous Interactions of gp78 E3 ligase CUE domain with polyubiquitin chains
- Multiple E3 ligases act as antiviral factors against SARS-CoV-2 via inducing the ubiquitination and degradation of ORF9b
- The Antibiotic Treatment Index: A Novel Tool to Improve Antibiotic Resistance Monitoring
- The Ubiquitin E3 Ligase MaLUL2 Is Involved in High Temperature-Induced Green Ripening in Banana Fruit
- Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe
- Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cells
- Auto-ubiquitination of Mdm2 Enhances Its Substrate Ubiquitin Ligase Activity*