Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
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Summary
It is concluded that the activation of the Akt/mTOR pathway and its downstream targets, p70S6K and PHAS-1/4E-BP1, is requisitely involved in regulating skeletal muscle fibre size, and that activation of this pathway can oppose muscle atrophy induced by disuse.
- Type
- article
- Published
- 2001-11-01
- Cited by
- 2,795
- References
- 54
- OpenAlex
- https://openalex.org/W1586159393
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16284975
Keywords
PI3K/AKT/mTOR pathway, Muscle hypertrophy, Protein kinase B, Calcineurin, Skeletal muscle
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- Skeletal muscle fibre plasticity in response to selected environmental and physiological stimuli.
- Autophagy and aging--importance of amino acid levels.
- Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase.
- Expression of beta-catenin is necessary for physiological growth of adult skeletal muscle.
- New fundamental resistance exercise determinants of molecular and cellular muscle adaptations
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- GSK-3beta activity is increased in skeletal muscle after burn injury in rats.
- Geometric control of myogenic cell fate
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- Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages
- Attenuation of skeletal muscle atrophy in cancer cachexia by d-myo-inositol 1,2,6-triphosphate
- Association of skeletal muscle wasting with treatment with sorafenib in patients with advanced renal cell carcinoma: results from a placebo-controlled study.
- HMB supplementation: clinical and athletic performance-related effects and mechanisms of action
- Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes.
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- The role of amino acids in skeletal muscle adaptation to exercise.
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