FOXO1 Regulates the Expression of 4E-BP1 and Inhibits mTOR Signaling in Mammalian Skeletal Muscle*
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Summary
It is shown that constitutively active FOXO1 inhibits mTOR signaling and protein synthesis, and this data suggest that FoxO1 may be an important therapeutic target for human diseases where anabolism is impaired.
- Type
- article
- Published
- 2007-07-20
- Cited by
- 110
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W17510058
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25635147
Keywords
Political science, Humanities, Philosophy
References
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- SPECIAL REVIEW SERIES ON ISCHEMIA/REPERFUSION INJURY: CLINICAL AND MICROCIRCULATORY VIEWS
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- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Cited by
- Cibles moléculaires de la myostatine impliquées dans l'hypertrophie musculaire chez la souris et le bovin
- Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
- Role of sphingolipids in muscle atrophy
- The function of Activin receptor type IIB signaling in adult skeletal muscle
- A differential pattern of gene expression in skeletal muscle of tumor‐bearing rats reveals dysregulation of excitation–contraction coupling together with additional muscle alterations
- Forkhead box O transcription factors as possible mediators in the development of major depression.
- CaMKII Protein Expression and Phosphorylation in Mouse Skeletal Muscle Following Atrophy and Hypertrophy
- Autophagy in Premature Senescent Cells Is Activated via AMPK Pathway
- Unraveling the role of FoxOs in bone - insights from mouse models
- Cellular mechanisms and local progenitor activation to regulate skeletal muscle mass
- Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model.
- Oxidative Stress, Molecular Inflammation and Sarcopenia
- Muscle degeneration in rotator cuff tears.
- The role of FoxO in the regulation of metabolism
- Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- Mechanisms regulating skeletal muscle growth and atrophy
- Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
- Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components.
- Identification of functional glucocorticoid response elements in the mouse FoxO1 promoter.
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