Forkhead transcription factors: key players in development and metabolism.
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Summary
Forkhead proteins are not among the largest transcription factor families, but display a remarkable functional diversity and are involved in a wide variety of biological processes.
- Type
- review
- Published
- 2002-10-01
- Cited by
- 907
- References
- 236
- Access
- Open access
- OpenAlex
- https://openalex.org/W2040604400
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9935821
Keywords
Biology, Key (lock), Transcription factor, Transcription (linguistics), Computational biology
References
- The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?
- The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
- Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
- The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
- Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia
- X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
- A fork in the road to fertility
- Foxe3 haploinsufficiency in mice: a model for Peters' anomaly.
- Smad4 and FAST-1 in the assembly of activin-responsive factor
- Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.
- The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25
- A mouse model for hereditary thyroid dysgenesis and cleft palate
- AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
- Genetic diversity and disease control in rice
- Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters
- The Mouse fkh-2 Gene
- Exposing the human nude phenotype
- Direct control of the Forkhead transcription factor AFX by protein kinase B
- The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
Cited by
- The hedgehog signaling pathway in cancer.
- Forkhead (FOX) transcription factors and the cell cycle: measurement of DNA binding by FoxO and FoxM transcription factors.
- Expression and phylogenetic analyses of three zebrafish FoxI class genes
- Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis
- Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct.
- The FOXP1 Transcription Factor is Expressed in the Majority of Follicular Lymphomas but is Rarely Expressed in Classical and Lymphocyte Predominant Hodgkin’s Lymphoma
- The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer.
- Generation of mice with a conditional Foxp2 null allele
- Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1
- Structural basis for DNA recognition by FOXO proteins.
- Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma
- The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.
- FOXR2 Promotes the Proliferation, Invasion, and Epithelial–Mesenchymal Transition in Human Colorectal Cancer Cells
- FOXD1, negatively regulated by miR-186, promotes the proliferation, metastasis and radioresistance of nasopharyngeal carcinoma cells
- The role played by alkaline phosphatase in lipid droplet formation in different lipid-storing cell types
- The Utilization of Mouse Models to Study Gene Functions: The Role of Foxn3 and Chd2 in Murine Development and Cancer
- The role of ghrelin in anorexia-cachexia syndromes.
- The genetic aetiology of otosclerosis in the population of Newfoundland and Labrador
- FOXL2 mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome
- The molecular mechanisms of PITX2 in tooth development and enamel defects in Axenfeld-Rieger Syndrome
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