New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies
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Summary
This review summarizes the major gene loci affecting LOAD identified by large GWASs and suggests that these may together affect LOAD pathogenesis in a complementary fashion.
- Type
- article
- Published
- 2018-02-01
- Cited by
- 31
- References
- 94
- OpenAlex
- https://openalex.org/W30381536
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53149208
Keywords
Medicine
References
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- Formaldehyde, Epigenetics, and Alzheimer’s Disease
- Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21.
- The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy
- Parkinson disease and the immune system — associations, mechanisms and therapeutics
- The Other Side of Alzheimer’s Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers
- Data-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer’s Disease
- Therapeutic Lessons to be Learned From the Role of Complement Regulators as Double-Edged Sword in Health and Disease
- Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders
- Neuroinflammation in Alzheimer’s Disease
- Disease-specific interactome alterations via epichaperomics: the case for Alzheimer’s disease
- Progression in Alzheimer’s Disease Correlates With Epigenetics and Cerebral Formaldehyde: From Potential Hereditary Mechanism and Environmental Factors to Therapeutic Measures
- Alternative Splicing Regulation of Low-Frequency Genetic Variants in Exon 2 of TREM2 in Alzheimer’s Disease by Splicing-Based Aggregation
- Remembering your A, B, C's: Alzheimer's disease and ABCA1
- Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
- Neuroinflammation as a Potential Therapeutic Target in Alzheimer’s Disease
- Inflammation—Cause or consequence of late onset Alzheimer’s disease or both? A review of the evidence
- Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
- Brain structure and allelic associations in Alzheimer's disease
- Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?
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