Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells
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Summary
It is suggested that NKCC1 is an essential mechanism in GBM cells to maintain K +</sup, Cl –, and volume homeostasis to counteract TMZ-induced loss of K<sup+, Cl– and AVD.
- Type
- article
- Published
- 2012-06-01
- Cited by
- 53
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W1966273336
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11408928
Keywords
Apoptosis, Bumetanide, Chemistry, Cancer cell, Cotransporter
References
- Phosphorylation state of the Na+–K+–Cl− cotransporter (NKCC1) in the gills of Atlantic killifish (Fundulus heteroclitus) during acclimation to water of varying salinity
- Abnormal GABAA Receptor-Mediated Currents in Dorsal Root Ganglion Neurons Isolated from Na–K–2Cl Cotransporter Null Mice
- Characterization of Glial Cell K-Cl Cotransport
- Ionic Mechanism of Ouabain-Induced Concurrent Apoptosis and Necrosis in Individual Cultured Cortical Neurons
- Expression of Voltage-Gated Chloride Channels in Human Glioma Cells
- p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.
- Na-K-Cl Cotransporter Contributes to Glutamate-Mediated Excitotoxicity
- PASK (Proline-Alanine-rich STE20-related Kinase), a Regulatory Kinase of the Na-K-Cl Cotransporter (NKCC1)*
- The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
- On the mechanism of ionic regulation of apoptosis: would the Na+/K+‐ATPase please stand up?
- Apoptosis, cell volume regulation and volume-regulatory chloride channels.
- Na-K-Cl Cotransporter-Mediated Intracellular Na+ Accumulation Affects Ca2+ Signaling in Astrocytes in an In Vitro Ischemic Model
- Cell shrinkage and monovalent cation fluxes: role in apoptosis.
- A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis*
- Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies
- Chloride accumulation drives volume dynamics underlying cell proliferation and migration.
- Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis.
- Inhibition of Protein Kinase Akt1 by Apoptosis Signal-regulating Kinase-1 (ASK1) Is Involved in Apoptotic Inhibition of Regulatory Volume Increase*
- Na+,K+,2Cl- cotransport and intracellular chloride regulation in rat primary sensory neurons: thermodynamic and kinetic aspects.
- Cationic Gradient Reversal and Cytoskeleton-independent Volume Regulatory Pathways Define an Early Stage of Apoptosis*
Cited by
- Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma
- The role of ion channels in malignant brain tumors
- Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.
- TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways
- Ion channels and transporters in the development of drug resistance in cancer cells
- Bumetanide-induced NKCC1 inhibition attenuates oxygen-glucose deprivation-induced decrease in proliferative activity and cell cycle progression arrest in cultured OPCs via p-38 MAPKs.
- Anti-angiogenic effects of bumetanide revealed by DCE-MRI with a biodegradable macromolecular contrast agent in a colon cancer model
- Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase
- Optimizing antiepileptic drug treatment in tumoral epilepsy
- L’épilepsie associée aux tumeurs cérébrales
- Ion transporters in brain tumors
- Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival.
- Role of Na+-K+-2Cl- Cotransporter 1 in Phenylephrine-Induced Rhythmic Contraction in the Mouse Aorta: Regulation of Na+-K+-2Cl- Cotransporter 1 by Ca2+ Sparks and KCa Channels
- WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
- Cation-chloride cotransporters in the nervous system
- Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients.
- RETRACTED ARTICLE: MiR-429 induces apoptosis of glioblastoma cell through Bcl-2
- Seizures and gliomas — towards a single therapeutic approach
- Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells
- WNK Kinase Signaling in Ion Homeostasis and Human Disease.
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