Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients.
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Summary
NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients andEGFR-mutated subgroup and novel therapeutic tactics could be developed by targeting NKCC1 protein.
- Type
- article
- Published
- 2016-04-01
- Cited by
- 22
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2208897378
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39320228
Keywords
Adenocarcinoma, Internal medicine, Medicine, Immunohistochemistry, Perineural invasion
References
- WHO classification of tumours of the lung, pleura, thymus and heart
- Cotransport of water by the Na+–K+–2Cl− cotransporter NKCC1 in mammalian epithelial cells
- Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells
- Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: pooled analysis
- NKCC1 cotransporters: keeping an ‘ion’ them
- Ion channels and transporters in the development of drug resistance in cancer cells
- Na-K-2Cl cotransporter inhibition impairs human lung cellular proliferation.
- EGFR Mutation Is Specific for Terminal Respiratory Unit Type Adenocarcinoma
- Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
- ROS1 gene rearrangement and copy number gain in non-small cell lung cancer
- Ion Channels in Cell Proliferation and Apoptotic Cell Death
- Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines.
- The role of ion channels and transporters in cell proliferation and cancer
- Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk.
- Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium.
- Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation
- High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features
- Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.
- International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
- Identification of key residues involved in the dimerization of the secretory Na+-K+-2Cl− cotransporter NKCC1
Cited by
- Quantitative analysis of U251MG human glioma cells invasion in organotypic brain slice co-cultures.
- Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells
- Dielectrophoretic properties distinguish responses to estrogen and fulvestrant in breast cancer cells
- NKCC1 promotes EMT‐like process in GBM via RhoA and Rac1 signaling pathways
- Valproic Acid Inhibits NA-K-2CL Cotransporter RNA Expression in Male But Not in Female Rat Thymocytes
- Sodium homeostasis in the tumour microenvironment
- Identifying Common Driver Pathways based on Pan-cancer Data
- NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas
- Blockade of Cell Volume Regulatory Protein NKCC1 Increases TMZ-Induced Glioma Apoptosis and Reduces Astrogliosis
- Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66
- A guide to plasma membrane solute carrier proteins
- Solute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis.
- Two novel models and a parthenogenetic algorithm for detecting common driver pathways from pan-cancer data
- Targeting the pH Paradigm at the Bedside: A Practical Approach
- Aberrant Expression of Sodium-Potassium-Chloride Cotransporter in Endometriosis
- Use of antihypertensive drugs and breast cancer risk: a two-sample Mendelian randomization study
- The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies
- Comprehensive analyses of solute carrier family members identify SLC12A2 as a novel therapy target for colorectal cancer
- Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study
- Dual Targeting of Brain Tumors and Their Environment by Bumetanide and Mebendazole
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