Ionic Mechanism of Ouabain-Induced Concurrent Apoptosis and Necrosis in Individual Cultured Cortical Neurons
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Summary
The results suggest that the neuronal death associated with Na+, K+-pump failure consists of concurrent apoptotic and necrotic components, mediated by intracellular depletion of K+ and accumulation of Ca2+ and Na+, respectively.
- Type
- article
- Published
- 2002-02-15
- Cited by
- 234
- References
- 109
- Access
- Open access
- OpenAlex
- https://openalex.org/W1684019827
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17231273
Keywords
Ouabain, Intracellular, Programmed cell death, Apoptosis, Chemistry
References
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- Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways.
- Ouabain Induces Apoptosis on PHA-Activated Lymphocytes
- Inhibition of Na+/K+-ATPase may be one mechanism contributing to potassium efflux and cell shrinkage in CD95-induced apoptosis
- Regulation of programmed cell death by interleukin-1 beta-converting enzyme family of proteases.
- The 55-kD Tumor Necrosis Factor Receptor and CD95 Independently Signal Murine Hepatocyte Apoptosis and Subsequent Liver Failure
- Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat
- Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.
- Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis
- NMDA Receptor Activation Inhibits Neuronal Volume Regulation after Swelling Induced by Veratridine-Stimulated Na+ Influx in Rat Cortical Cultures
- Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.
- Cell death: the significance of apoptosis.
- The biochemistry of programmed cell death
- Dysregulation of apoptosis in cancer.
- Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury
- Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin.
- The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes
- Inversion of the intracellular Na(+)/K(+) ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis.
Cited by
- Investigation of the neuronal death mode induced by glutamate treatment in serum-, antioxidant-free primary cultured cortical neurons.
- Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel.
- Nano‐CuO inhibited voltage‐gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G‐proteins pathway
- Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
- Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer
- Sinalização inflamatória e a modulação da expressão de genes induzida pela ação da ouabaína nas isoformas a1, a2 - Na+, K+- ATPase em células da glia.
- Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism.
- Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications
- Novel regulation of Na+, K+‐ATPase by Src tyrosine kinases in cortical neurons
- Pathogenesis of Human Immunodeficiency Virus Type-1 (HIV-1)-Associated Dementia: Role of Voltage-Gated Potassium Channels.
- Role of Ion Transport in Control of Apoptotic Cell Death
- Bacoside A: Role in Cigarette Smoking Induced Changes in Brain
- Inhibition of Na+,K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+]i/[K+]i ratio.
- A Fluorescence Microplate Assay Using Yopro-1 to measure apoptosis: Application to HL60 Cells Subjected to Oxidative stress
- Apoptosis vs. oncosis: role of cell volume and intracellular monovalent cations.
- Potassium aspartate inhibits SH-SY5Y cell damage and apoptosis induced by ouabain and H2O2.
- An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death*
- Effects of alpha- and theta-cypermethrin insecticide on transient outward potassium current in rat hippocampal CA3 neurons
- Liver and kidney damage induced by 4-aminopyridine in a repeated dose (28 days) oral toxicity study in rats: gene expression profile of hybrid cell death.
- Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells
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