Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
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Summary
Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptoses induced by Fas antibody, despite this defect in apoptosis.
- Type
- article
- Published
- 1995-03-31
- Cited by
- 1,749
- References
- 38
- OpenAlex
- https://openalex.org/W1964977785
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44773115
Keywords
Apoptosis, Proinflammatory cytokine, Interleukin, Cytokine, Tumor necrosis factor alpha
References
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- Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor.
- Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.
- Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.
- Activation of intracellular proteases is an early event in TNF-induced apoptosis.
- CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
- IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
- The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
- Prevention of vertebrate neuronal death by the crmA gene.
- Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
- Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2.
- Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
- Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
- Viral inhibition of inflammation. Cowpox virus encodes an inhibitor of the interleukin 1β converting enzyme.
- Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Cited by
- Caspases in cell death.
- Mice Deficient in Interleukin-1β Converting Enzyme
- Role of multiple cellular proteases in the execution of programmed cell death
- Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.
- Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells
- Cleavage of caspase family members by granzyme B: a comparative study in vitro
- Signaling events in T lymphocytes leading to cellular activation or programmed cell death.
- Activation of Caspase-2 in Apoptosis*
- Granzyme B-induced apoptosis.
- The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
- COP, a Caspase Recruitment Domain-containing Protein and Inhibitor of Caspase-1 Activation Processing*
- Serpins and regulation of cell death.
- Oxysterols induce interleukin‐1β production in human macrophages
- Ribavirin inhibits DNA, RNA, and protein synthesis in PHA‐stimulated human peripheral blood mononuclear cells: Possible explanation for therapeutic efficacy in patients with chronic HCV infection
- Prevention of nuclear localization of activated caspases correlates with inhibition of apoptosis
- Ceramide and the regulation of apoptosis and the stress response.
- Rosmarinic Acid, Active Component of Dansam-Eum Attenuates Ototoxicity of Cochlear Hair Cells through Blockage of Caspase-1 Activity
- Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury
- Molecular and cellular mechanisms of T lymphocyte apoptosis.
- The structural basis for receptor recognition of human interleukin-18
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