Activation of Caspase-2 in Apoptosis*
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Summary
It is suggested that the first cleavage of caspase-2 is accomplished by a caspases-3-like activity, and other ICE-like proteases less sensitive to DEVD-CHO may be responsible for activation of cspase-3 and loss of mitochondrial function.
- Type
- article
- Published
- 1997-08-22
- Cited by
- 190
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W9261102
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25633040
Keywords
Computer science
References
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- Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product (*)
- Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes
- Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction.
- Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
- Molecular cloning of the interleukin-1 beta converting enzyme.
- Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
- In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
- Prevention of vertebrate neuronal death by the crmA gene.
- Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
- Involvement of an ICE-like protease in Fas-mediated apoptosis
Cited by
- The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
- Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60.
- NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
- Uncovering a Novel Role of the Apoptotic Initiator Caspase, Caspase-2
- Crosstalk between the mitogen-activated protein kinase signaling and protease pathways in a model of glutamate-induced oxidative toxicity
- Protein Dimerization and Oligomerization in Biology
- Molecular Biology In Cellular Pathology
- The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System
- Caspase-9/-3 Activation and Apoptosis Are Induced in Mouse Macrophages upon Ingestion and Digestion of Escherichia coli Bacteria1
- A caspase‐3‐dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell‐specific caspase‐2 activation in the retinal cell death
- BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia.
- Two caspase‐2 transcripts are expressed in rat hippocampus after global cerebral ischemia
- Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.
- Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling.
- Novel genomic determinants of apoptotic defects in acute lymphoblastic leukemia
- Liver-specific overexpression of the IGF2 mRNA binding protein p62 induces a fatty liver disease phenotype
- Caspase‐2 activation is redundant during seizure‐induced neuronal death
- Programmed cell death in virus infections of the nervous system.
- Die Rolle des Tumorsuppressorproteins p53 bei der Apoptoseregulation glatter Gefäßmuskelzellen der Neointima
- TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death
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