Mice Deficient in Interleukin-1β Converting Enzyme
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Summary
The crystal structure of ICE reveals that the active enzyme is composed of two 20-k Da and two 10-kDa subunits to form a tetramer (7,8), and this structure is similar to that of a Tournaisian tetramer.
- Type
- article
- Published
- 1998-01-01
- Cited by
- 24
- References
- 54
- OpenAlex
- https://openalex.org/W2880843
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:80785888
Keywords
Tetramer, Enzyme, Gene isoform, Peptide sequence, Chemistry
References
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- Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.
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- Activation of intracellular proteases is an early event in TNF-induced apoptosis.
- CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
- Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
- IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
- Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
- The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice.
- Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product (*)
- The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
- A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice
- Molecular cloning of the interleukin-1 beta converting enzyme.
- Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.
Cited by
- Expression, Purification, and Characterization of Caspases
- Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β1
- Neutrophils are major contributors to intraparenchymal lung IL-1 beta expression after hemorrhage and endotoxemia.
- Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector
- Increased Interleukin-1 (IL-1) and Imbalance between IL-1 and IL-1 Receptor Antagonist during Acute Inflammation in Experimental Shigellosis
- IL-1β Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs
- Activation of the Hypothalamic- Pituitary-Adrenal Axis in IL-1β-Converting Enzyme-Deficient Mice
- ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules
- Mechanisms of Behavioral and Neuroendocrine Effects of Interleukin‐1 in Mice
- A new model of stroke and ischemic seizures in the immature mouse.
- Interleukin-1β, Interleukin-18, and Interferon-γ Expression in the Cerebrospinal Fluid of Premature Infants with Posthemorrhagic Hydrocephalus—Markers of White Matter Damage?
- FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
- NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
- Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta.
- Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
- Contribution of Toll‐like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration
- Neurochemical disorders at the hypoxic-ischemic encephalopathy in newborns
- UNIVERSITY OF SÃO PAULO INSTITUTE OF BIOMEDICINE AMRITA JHA KUMAR SEX DIFFERENCES IN NEONATAL ANOXIA: A Behavioural and Histological Study in Wistar Rats. São Paulo 2019 AMRITA JHA KUMAR SEX DIFFERENCES IN NEONATAL ANOXIA:
- IL-1 b Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs
- The Role of Caspases in Development , Review Immunity , and Apoptotic Signal Transduction : Lessons from Knockout Mice and-12
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