Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages1
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Summary
Results collectively indicate that TLR4 negatively regulates the degradation of engulfed cells in macrophages via a pathway independent of NF-κB.
- Type
- article
- Published
- 2004-02-15
- Cited by
- 121
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1944631098
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31724505
Keywords
Phagosome, Endosome, Cell biology, Phagocytosis, TLR4
References
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- Assay of phagosome-lysosome fusion.
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- Cell death: the significance of apoptosis.
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- Clearing the way to mechanisms of autoimmunity
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- Corpse clearance defines the meaning of cell death
- Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages1
- Toll-like receptors in the induction of the innate immune response
- Horizontal Transfer of DNA by the Uptake of Apoptotic Bodies
- Toll-like receptors: key mediators of microbe detection.
- Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility
- Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells.
- Inhibition of Tumor Necrosis Factor-α-induced Nuclear Translocation and Activation of NF-κB by Dehydroxymethylepoxyquinomicin*
- Phagocytosis of bacterial pathogens: implications in the host response.
- Horizontal transfer of oncogenes by uptake of apoptotic bodies
- Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: Cell fate is regulated at the level of gene expression
- Phagocytosis and innate immunity.
Cited by
- The Immune Escape Mechanisms of Mycobacterium Tuberculosis
- The nature of memory CD8+ T-cell responses in bovine tuberculosis
- Optimisation d’une stratégie thérapeutique antitumorale conventionnelle par association à une immunothérapie : etude de phase I combinant l’Imatinib à l’Interleukine-2
- Cell-Death-Associated Molecular Patterns As Determinants of Cancer Immunogenicity
- Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer
- Presentation of phagocytosed antigens by MHC class I and II
- Integrin β1 Regulates Phagosome Maturation in Macrophages through Rac Expression1
- The role of the innate immune system in the clearance of apoptotic cells
- Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
- Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice1
- TLR2-Mediated Survival of Staphylococcus aureus in Macrophages: A Novel Bacterial Strategy against Host Innate Immunity1
- Dendritic cell vaccination and other strategies to tip the balance of the immune system
- Desirable cell death during anticancer chemotherapy
- Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier
- Enhanced Apoptotic Cell Clearance Capacity and B Cell Survival Factor Production by IL-10-Activated Macrophages: Implications for Burkitt’s Lymphoma1
- Immunogenicity of 56°C and UVC‐treated prostate cancer is associated with release of HSP70 and HMGB1 from necrotic cells
- The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?
- Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.
- Fluorescent Imaging of Antigen Released by a Skin-Invading Helminth Reveals Differential Uptake and Activation Profiles by Antigen Presenting Cells
- Immunology: The pick of the nibbled bits
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