Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era.
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Summary
Novel prognostic factors at CLL diagnosis that have shown an impact on the prognosis and outcomes of this disease are reviewed to recommend analyzing these factors at diagnosis for better prognostication.
- Type
- review
- Published
- 2015-10-01
- Cited by
- 65
- References
- 84
- Access
- Open access
- OpenAlex
- https://openalex.org/W1941121600
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8778215
Keywords
Medicine, Chronic lymphocytic leukemia, Leukemia, MEDLINE, Oncology
References
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- Non-Hodgkin’s Lymphomas, Version 4.2014
- Clinical staging of chronic lymphocytic leukemia.
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- Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
- Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.
- ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): High complete- response rate and durable disease control.
- Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B‐cell chronic lymphocytic leukemia
- Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B‐chronic lymphocytic leukaemia
- Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients
- NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment
- Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.
- De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience.
- Genetic Abnormalities in Chronic Lymphocytic Leukemia: Where We Are and Where We Go
- miR-15 and miR-16 induce apoptosis by targeting BCL2.
- NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL
- Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib.
- Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group.
Cited by
- Progesterone and Synthetic Progestin Controversies.
- The role of idelalisib in the treatment of relapsed and refractory chronic lymphocytic leukemia
- Thank You JAMA Oncology Authors, Peer Reviewers, and Readers.
- Principles of analytical validation of next-generation sequencing based mutational analysis for hematologic neoplasms in a CLIA-certified laboratory
- The addition of ofatumumab to the conditioning regimen does not improve the outcome of patients with high-risk CLL undergoing reduced intensity allogeneic haematopoietic cell transplantation: a pilot trial from the GETH and GELLC (CLL4 trial)
- Dielectrophoretic recovery of DNA from plasma for the identification of chronic lymphocytic leukemia point mutations.
- Metaphase Cytogenetics in Chronic Lymphocytic Leukemia
- Lenalidomide in chronic lymphocytic leukemia
- Clinical pathways in chronic lymphocytic leukemia: Challenges and solutions
- A Novel Assay for the Identification of NOTCH1 PEST Domain Mutations in Chronic Lymphocytic Leukemia
- Therapeutic Targeting of Tumorigenesis and Tumor Disease -For Clinical Analysis of Epigenetics and Epigenome
- Advances in the treatment of relapsed/refractory chronic lymphocytic leukemia
- Progressive telomere shortening is part of the natural history of chronic lymphocytic leukaemia and impacts clinical outcome: evidences from long term follow‐up
- Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia
- Association between immunoglobulin heavy-chain variable region mutational status and isolated favorable baseline genomic aberrations in chronic lymphocytic leukemia
- Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia
- New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia
- Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome
- Prognostic Testing Patterns and Outcomes of Chronic Lymphocytic Leukemia Patients Stratified by Fluorescence In Situ Hybridization/Cytogenetics: A Real‐world Clinical Experience in the Connect CLL Registry
- Cytogenetic/mutation profile of chronic lymphocytic leukemia/malignant melanoma collision tumors of the skin
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