p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction.

Keywords

Cyclin-dependent kinase 5, Presenilin, Catenin, Cell biology, Phosphorylation

References

• Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.John I. Lew, Robert J. Winkfein, Hemant K. Paudel — 1992
• Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegenerationGentry N. Patrick, Lawrence Zukerberg, Margareta Nikolić — 1999
• Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosisZhuohua Zhang, Henrike Hartmann, Viet Minh — 1998
• Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.Hemant K. Paudel, John I. Lew, Ali Z — 1993
• Neurotoxicity induces cleavage of p35 to p25 by calpainMing‐Sum Lee, Young T. Kwon, Mingwei Li — 2000
• Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complexMasaki Nishimura, Gang Yu, Georges Lévesque — 1999
• Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling PathwayDavid E. Kang, Salvador Soriano, Matthew P. Frosch — 1999
• The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activityMargareta Nikolić, Margaret M. Chou, Wange Lu — 1998
• Tau protein kinase II has a similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins.Shin‐ichi Hisanaga, K. Ishiguro, Tsuneko Uchida — 1993
• Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neuronsJames Bibb, Gretchen L. Snyder, Akinori Nishi — 1999
• Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.Li‐Huei Tsai, Takao Takahashi, Verne S. Caviness — 1993
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APCPatrice J. Morin, Andrew B. Sparks, Vladimír Kořínek — 1997
• Association of Neurofilament Proteins with Neuronal Cdk5 Activator*Robert Z. Qi, Damu Tang, Xiaodong Zhu — 1998
• Differential Cellular Phosphorylation of Neurofilament Heavy Side‐Arms by Glycogen Synthase Kinase‐3 and Cyclin‐Dependent Kinase‐5Sonia Guidato, Li‐Huei Tsai, Jim Woodgett — 1996
• Tyrosine phosphorylation and cadherin/catenin functionJuliet M. Daniel, Albert B. Reynolds — 1997
• Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25*Gen-ichi Kusakawa, Taro Saito, Reiko Onuki — 2000
• Expression of β-catenin and the adenomatous polyposis coli tumour suppressor protein in mouse neocortical cells in vitroEwan E. Morrison, Jon M. Askham, Patricia M. Clissold — 1997
• Presenilin 1 interaction in the brain with a novel member of the Armadillo familyJianhua Zhou, Udaya Liyanage, Miguel Medina — 1997
• Molecular Characterization of a Neuronal‐Specific Protein that Stimulates the Activity of Cdk5K. Taranath Shetty, Stefanie Kaech, William T. Link — 1995
• Neuronal Cdc2-like Kinase (Nclk) Binds and Phosphorylates the Retinoblastoma Protein*Ki‐Young Lee, Caren C. Helbing, Kyu‐Sil Choi — 1997

Cited by

• Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.Christiana. Tings — 2006
• Role of protein kinases in neurodegenerative disease: cyclin-dependent kinases in Alzheimer's disease.Edward, A. Monaco III — 2005
• Molecular and Cellular Biology of Neuroprotection in the CNSChristian Alzheimer, Of Neuroprotection, Christian Alzheimer — 2002
• p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1Liyun Zhang, Sylvia Bonilla, Yuqing Zhang — 2014
• Regulation of synaptic function and plasticity by cyclin-dependent kinase 5Susan C. Su — 2012
• Axonal cap-dependent translation regulates presynaptic p35Kuangfu Hsiao, Ozlem Bozdagi, Deanna L. Benson — 2013
• Neuronal survival and cell death signaling pathways.Richard S. Morrison, Yoshito Kinoshita, Mark D. Johnson — 2002
• Presenilin 1 Independently Regulates β-Catenin Stability and Transcriptional Activity*Richard Killick, Claire C. Pollard, Ayodeji A. Asuni — 2001
• In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5Anne Jämsä — 2007
• Cyclin-dependent kinase 5 (CDK5) and neuronal cell deathJochen H. Weishaupt, Clemens Neusch, Mathias Bähr — 2003
• Preclinical studies of roscovitineMarina Vita — 2005
• A decade of CDK5Rani Dhavan, Li‐Huei Tsai — 2001
• Microarray‐based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progressionGunnar Wrobel, Peter Roerig, Felix Kokocinski — 2005
• Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5Sashi Kesavapany, Ya‐Li Zheng, Niranjana D. Amin — 2007
• Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide.Sashi Kesavapany, Bingsheng Li, Niranjana D. Amin — 2004
• Cables links Robo-bound Abl kinase to N-cadherin-bound β-catenin to mediate Slit-induced modulation of adhesion and transcriptionJinseol Rhee, Tim Buchan, Lawrence Zukerberg — 2007
• Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.Kwok‐Fai Lau, David Howlett, Sashi Kesavapany — 2002
• Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.Ko-Woon Lee, Yong Kim, Amie M. Kim — 2006
• Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.Rosa Rademakers, Kristel Sleegers, Jessie Theuns — 2005
• Presenilin-interacting proteinsQi Chen, David Schubert — 2002

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• Presenilin 1 Independently Regulates β-Catenin Stability and Transcriptional Activity*Richard Killick, Claire C. Pollard, Ayodeji A. Asuni — 2001
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