Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.
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Summary
Compared with other cell division cycle kinases to which it is closely related, cdk5 appears not to be expressed in dividing cells in the developing brain and may have a role in neuronal differentiation but not in thecell division cycle in the embryonic nervous system.
- Type
- article
- Published
- 1993-12-01
- Cited by
- 486
- References
- 66
- OpenAlex
- https://openalex.org/W1905265488
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9592897
Keywords
Cyclin-dependent kinase 5, Biology, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cell biology
References
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- A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
- Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.
- Distribution and phosphorylation of the growth-associated protein GAP- 43 in regenerating sympathetic neurons in culture
- Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain
- Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products
- Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.
- Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes.
- Neocortical histogenesis in normal and reeler mice: a developmental study based upon [3H]thymidine autoradiography.
- Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.
- Cell cycle gets more cyclins
- Time of origin of corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: An autoradiographic analysis
Cited by
- Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
- Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
- Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death
- The role of the p35/cdk5 kinase in cortical development.
- Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
- Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators.
- Behandlung mit CDK5 Inhibitor bei der Myelin Oligodendrozyten Glykoprotein (MOG) induzierten experimentellen autoimmunen Encephalomyelitis (EAE)
- Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes.
- Dictyostelium cell-fate bias is regulated antagonistically by the Retinoblastoma orthologue RblA and the cyclin-dependent kinase Cdk1
- Role of protein kinases in neurodegenerative disease: cyclin-dependent kinases in Alzheimer's disease.
- Kinase Signalling in Huntington's Disease
- Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae
- ROLE OF TALIN1 PHOSPHORYLATION IN BETA1 INTEGRIN ACTIVATION AND PROSTATE CANCER METASTASIS
- Biochemical analysis of genetically-modified mice with learning and memory phenotypes
- Normal and Abnormal Development of the Cortex
- Germ Cell Development, Division, Disruption and Death
- Rôle des microtubules et de l'acto-myosine dans la migration des interneurones corticaux
- D-type cyclins in Xenopus laevis
- Relay of cyclin-dependent kinases in the regulation of axonal growth.
- Alzheimer’s Disease: Lessons from Cell Biology
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