Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
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Summary
It is shown that cyclin-dependent kinase 5 (CDK5), a known regulator of migration in neuronal development, plays an important role in prostate cancer motility and metastasis.
- Type
- article
- Published
- 2006-08-01
- Cited by
- 160
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W16885348
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1446437
Keywords
German, European union, Political science, Foreign policy, Public administration
References
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- Matrix metalloproteinases: a tail of a frog that became a prince
- The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
- CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13.
- Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival
- Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.
- p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction.
- p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment
- Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.
- Tumor cells caught in the act of invading: their strategy for enhanced cell motility.
- Mechanisms of cancer cell invasion.
- Angiogenesis and its role in colorectal tumor and metastasis formation.
- Challenges in the development of anti-epidermal growth factor receptor therapies in breast cancer.
- Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
- Regulation of the interaction between PIPKIγ and talin by proline-directed protein kinases
- Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system.
- Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells.
- p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
Cited by
- Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis
- [Comparative analysis of gene expression in normal and cancer human prostate cell lines].
- ROLE OF TALIN1 PHOSPHORYLATION IN BETA1 INTEGRIN ACTIVATION AND PROSTATE CANCER METASTASIS
- Rôle de la protéine Cdk5 en réponse aux dommages de l’ADN : implications dans les points de contrôle S et G2/M
- CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis
- Dietary Lutein Modulates Growth and Survival Genes in Prostate Cancer Cells
- Glutathione‐S‐transferase P1 is a critical regulator of Cdk5 kinase activity
- Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex
- The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine.
- Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis
- Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread—Identification of a Promising Novel therapeutic target
- Cyclin-dependent kinase 5 regulates the proliferation, motility and invasiveness of lung cancer cells through its effects on cytoskeletal remodeling.
- Dietary lutein modulates expression of prostate cancer biomarker genes in human prostate cancer cell line
- Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration–proliferation dichotomy
- Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora.
- Therapeutic targeting of replicative immortality
- Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain.
- Targeting aurora kinases: a novel approach to curb the growth & chemoresistance of androgen refractory prostate cancer.
- Re-thinking cell cycle regulators: the cross-talk with metabolism
- Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases
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