IgG Fc receptors.
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Summary
Fc gamma Rs offer a paradigm for the biological significance of balancing activation and inhibitory signaling in the expanding family of activation/inhibitory receptor pairs found in the immune system.
- Type
- review
- Published
- 2001-04-01
- Cited by
- 1,845
- References
- 96
- OpenAlex
- https://openalex.org/W1903287340
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27144416
Keywords
Biology, Receptor, Effector, Immune system, Cell biology
References
- A complementary DNA clone for a macrophage-lymphocyte Fc receptor
- Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo.
- Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling.
- A New Small Molecule C5a Receptor Antagonist Inhibits the Reverse-Passive Arthus Reaction and Endotoxic Shock in Rats1
- Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.
- Inhibitory pathways triggered by ITIM-containing receptors.
- Crystal structure of the human leukocyte Fc receptor, FcγRIIa.
- Molecular basis of Fc receptor function.
- Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.
- Immune Complex and Fc Receptor-Mediated Augmentation of Antigen Presentation for in Vivo Th Cell Responses1
- Dendritic cells and the control of immunity
- Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies.
- Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.
- Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors.
- IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice.
- The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex
- Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors.
- Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis.
- Function and regulation of a murine macrophage-specific IgG Fc receptor, Fc gamma R-alpha
- Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.
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- Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing.
- Systemic lupus erythematosus and the type I interferon system
- B Lymphocyte Selection and Survival in Systemic Lupus
- Therapeutic immunomodulation of allergic lung disease using regulatory dendritic cells in a mouse model of asthma
- Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells.
- Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response.
- An essential function for the calcium-promoted Ras inactivator in Fcγ receptor–mediated phagocytosis
- Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes.
- Affinity of C-reactive protein toward FcgammaRI is strongly enhanced by the gamma-chain.
- Regulation of lung inflammation in the model of IgG immune-complex injury.
- Neutrophils in antibody-based immunotherapy of cancer
- Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity
- Fusion of the Fc part of human IgG1 to CD14 enhances its binding to gram-negative bacteria and mediates phagocytosis by Fc receptors of neutrophils.
- Fcγ receptors in Norwegian multiple sclerosis patients and healthy controls
- Toward aggregation-resistant antibodies by design.
- Application of Fluorescent Monocytes for Probing Immune Complexes on Antigen Microarrays
- Intravenous Immunoglobulin (IVIG) Attenuates TNF-induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression
- Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice
- Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis
- Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer
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