Therapeutic immunomodulation of allergic lung disease using regulatory dendritic cells in a mouse model of asthma
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Summary
It is reported herein that IL-10-treated dendritic cells (DC) can be used effectively to reverse established severe asthma-like disease in a mouse model and it is speculated that infectious tolerance sustains this regulatory activity during the 32-week period in which the authors have observed tolerance to be in place.
- Type
- article
- Published
- 2009-01-01
- Cited by
- 6
- References
- 366
- Access
- Open access
- OpenAlex
- https://openalex.org/W15202316
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81495067
Keywords
Immunology, Asthma, Medicine, Disease, Dendritic cell
References
- Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects.
- Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.
- Active anaphylaxis in IgE-deficient mice
- Airway hyperresponsiveness: first eosinophils and then neuropeptides.
- T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.
- Airway hyperreactivity in subjects with tetraplegia is associated with reduced baseline airway caliber.
- Antigen Transmission by Replicating Antigen-Bearing Dendritic Cells1
- CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide.
- Low-affinity receptor for IgE on human bronchial epithelial cells in asthma.
- Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats.
- Anti-Interleukin-5 Monoclonal Antibodies
- Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow.
- The pathobiology of bronchial asthma.
- Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells.
- An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model
- The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.
- The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review
- Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides.
- Emergence of regulatory CD4+ T cell response to repetitive stimulation with antigen-presenting cells in vitro: implications in designing antigen-presenting cell-based tumor vaccines.
- Induction of antitumor immunity using bone marrow-generated dendritic cells.
Cited by
- Therapeutic induction of tolerance by IL‐10‐differentiated dendritic cells in a mouse model of house dust mite‐asthma *
- Regulatory Dendritic Cells for Immunotherapy in Immunologic Diseases
- Dendritic Cell Control of Immune Responses
- The interactions of tolerogenic dendritic cells, induced regulatory T cells and antigen-specific IgG1-secreting plasma cells in asthma
- Contributions of direct versus indirect mechanisms for regulatory dendritic cell suppression of asthmatic allergen-specific IgG1 antibody responses
- CD40 signaling augments IL-10 expression and the tolerogenicity of IL-10-induced regulatory dendritic cells
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