Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
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Summary
The timing and duration of stress response may be critical for delineating an immune response in the brain thus probably explain the dual role of GCs and/or chronic stress in different animal models of PD.
- Type
- review
- Published
- 2015-08-14
- Cited by
- 44
- References
- 197
- Access
- Open access
- OpenAlex
- https://openalex.org/W1876851010
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16831674
Keywords
Microglia, Neuroscience, Parkinson's disease, Chronic stress, Relevance (law)
References
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- The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma.
- α-Synuclein oligomers and clinical implications for Parkinson disease
- Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels
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- G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndrome
- Chronic exposure to corticosterone enchances the neuroinflammatory and neurotoxic responses to methamphetamine
- Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse.
- From shell shock and war neurosis to posttraumatic stress disorder: a history of psychotraumatology
- Effects of mood, motivation, stress and alertness on the performance in Parkinson's disease.
- The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
- Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system.
- Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System
Cited by
- Microglia–blood vessel interactions: a double-edged sword in brain pathologies
- Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders.
- Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
- Clematichinenoside Serves as a Neuroprotective Agent Against Ischemic Stroke: The Synergistic Action of ERK1/2 and cPKC Pathways
- Microglia in Physiology and Disease.
- Charnoly body as a novel biomarker of nutritional stress in Alzheimer’s Disease
- Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress
- Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?
- Psychological Stress and Changes of Hypothalamic-Pituitary-Adrenal Axis in Patients with “De Novo” Parkinson’s Disease
- WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation
- Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke
- Microglia: Housekeeper of the Central Nervous System
- The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma
- Neuroimmunomodulatory properties of DPSCs in an in vitro model of Parkinson's disease
- Affective immunology: where emotions and the immune response converge
- THE PHYSIOLOGICAL RESPONSE OF RESIDENT MACROPHAGES TO THE ESTROGEN SURGE
- Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization
- An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
- Early Life Stress, Depression And Parkinson’s Disease: A New Approach
- IGF-1, Inflammation and Retinal Degeneration: A Close Network
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