Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System
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Summary
The results suggest that the nigrostriatal dopaminergic system is susceptible to damage by inflammatory events and that these may be implicated in neurodegeneration processes such as Parkinson's disease.
- Type
- article
- Published
- 1998-04-01
- Cited by
- 392
- References
- 57
- OpenAlex
- https://openalex.org/W1966905916
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11483415
Keywords
Dopaminergic, Nigrostriatal pathway, Parkinson's disease, Lipopolysaccharide, Chemistry
References
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Cited by
- Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.
- Effect of intracerebroventricular injection of lipopolysaccharide on the tuberoinfundibular dopaminergic system of the rat.
- Glucocorticoids: Protectors of the Brain during Innate Immune Responses
- Vulnerability of dopaminergic amacrine cells and optic nerve myelination to prenatal endotoxin exposure.
- Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway.
- Ageing as a primary risk factor for Parkinson’s disease: evidence from studies of non-human primates
- The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
- Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system.
- Microglial cells in neurodegenerative disorders.
- Aging Effects on Optic Nerve Neurodegeneration
- Nuclear receptors, inflammation, and neurodegenerative diseases.
- MPTP: insights into parkinsonian neurodegeneration.
- Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a potential, new model of Parkinson's disease.
- Pharmacological models of Parkinson's disease in rodents.
- Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
- Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation.
- Perfluorooctane sulfonate mediates microglial activation and secretion of TNF-α through Ca²⁺-dependent PKC-NF-кB signaling.
- The neuroprotective role of osteopontin in in-vitro and in-vivo models of Parkinson's disease
- Matrix Metalloproteinase Expression in Models of Parkinson's Disease
- The Effect of Different Microglial Activation States on the Survival of Retinal Ganglion Cells
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