Microglia derived from the axotomized adult rat facial nucleus uptake glutamate and metabolize it to glutamine in vitro
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Summary
Results demonstrate that axoFN‐microglia express functional GLT‐1 and GS proteins, and are strongly suggested to serve as Glu scavengers in vivo.
- Type
- article
- Published
- 2017-01-01
- Cited by
- 8
- References
- 55
- OpenAlex
- https://openalex.org/W2546440307
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3992201
Keywords
Microglia, Glutamine, Glutamate receptor, Glutamine synthetase, Neuroglia
References
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- Glutamine synthetase in muscle and kidney.
- Microglial motility in the rat facial nucleus following peripheral axotomy
- Transfer of glutamine between astrocytes and neurons
- Neuronal Regulation of Glutamate Transporter Subtype Expression in Astrocytes
- Protein measurement with the Folin phenol reagent.
- Neurones express glutamine synthetase when deprived of glutamine or interaction with astrocytes
- Mechanisms of excitotoxicity in neurologic diseases
- Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.
- Macrophage‐colony stimulating factor as an inducer of microglial proliferation in axotomized rat facial nucleus
- Glutamate released by Japanese encephalitis virus‐infected microglia involves TNF‐α signaling and contributes to neuronal death
- Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
- Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy.
- Modulation of GABA receptor subunits in rat facial motoneurons after axotomy.
- Astrocytic control of glutamatergic activity: astrocytes as stars of the show.
- A novel recovery system for cultured cells using plasma-treated polystyrene dishes grafted with poly(N-isopropylacrylamide).
- Modulation of the glutamatergic receptors (AMPA and NMDA) and of glutamate vesicular transporter 2 in the rat facial nucleus after axotomy.
- The microglia/macrophage response in the neonatal rat facial nucleus following axotomy.
- Tumor necrosis factor-α modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis
- Functions of glutamate transporters in the brain.
Cited by
- Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells
- Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase
- A Protective Role of Translocator Protein in Alzheimer's Disease Brain.
- Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system.
- Events Occurring in the Axotomized Facial Nucleus
- Mechanisms of Microglia Proliferation in a Rat Model of Facial Nerve Anatomy
- Metabolic reprogramming of microglia and astrocytes is a regulatory factor of neuroinflammation in ischemic stroke
- Metabolic Reprogramming of Microglia in Neuroinflammation and Depression
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