Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
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Summary
Findings indicate that the glucose and amino acid deficiency conditions imposed by STS promote an anti-Warburg effect characterized by increased oxygen consumption but failure to generate ATP, resulting in oxidative damage and apoptosis.
- Type
- article
- Published
- 2015-03-18
- Cited by
- 158
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1866746139
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:779729
Keywords
Warburg effect, Glutaminolysis, Oxidative stress, Oxidative phosphorylation, Apoptosis
References
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- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- Evidence for Ectopic Aerobic ATP Production on C6 Glioma Cell Plasma Membrane
- Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
- Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
- Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
- Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.
- The permeability transition pore complex in cancer cell death
- Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
- CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
- Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake
- SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer*
- The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
- Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy
- Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A.
- Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
Cited by
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- The influence of ketogenic therapy on the 5 R’s of radiobiology
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- Fasting and apoptosis: a mini review
- Polymer nanoparticle delivery of dichloroacetate and DACH-Pt to enhance antitumor efficacy and lower systemic toxicity.
- AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation
- Ramadan Fasting and Patients with Cancer: State-of-the-Art and Future Prospects
- Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt
- Nutrient restriction in combinatory therapy of tumors
- Fasting and Caloric Restriction in Cancer Prevention and Treatment
- Resilience in Aging Mice.
- Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma
- Short-term starvation attenuates liver ischemia-reperfusion injury (IRI) by Sirt1-autophagy signaling in mice.
- Immune by Heart: Unexpected Observations Inspiring Perspective Therapeutic/Preventive Strategies against Cancer
- Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo.
- Pyruvate dehydrogenase expression is negatively associated with cell stemness and worse clinical outcome in prostate cancers
- NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase
- Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS
- Protective effects of short-term dietary restriction in surgical stress and chemotherapy
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