Adaptive immune function in critical illness
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Summary
This review is being published to update the literature on the function of the adaptive immune system in critical illness, specifically sepsis and acute lung injury, and to focus on the role of T cells in these syndromes.
- Type
- review
- Published
- 2016-06-01
- Cited by
- 8
- References
- 93
- OpenAlex
- https://openalex.org/W2338834006
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37704160
Keywords
Medicine, Immune system, Sepsis, Proinflammatory cytokine, Immunology
References
- The late phase of sepsis is characterized by an increased microbiological burden and death rate
- Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
- Prolonged Lymphopenia, Lymphoid Depletion, and Hypoprolactinemia in Children with Nosocomial Sepsis and Multiple Organ Failure1
- Cytomegalovirus Reactivation in Critically-Ill Immunocompetent Patients
- Perforin and granzymes: function, dysfunction and human pathology
- Control of regulatory T cell migration, function and homeostasis
- IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis
- Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.
- Impaired antigen presentation by human monocytes during endotoxin tolerance.
- Regulatory T Cells and Foxp3
- Effect of Regulatory T Cells on Promoting Apoptosis of T Lymphocyte and Its Regulatory Mechanism in Sepsis
- Unexpected Role for Adaptive αβTH17 Cells in Acute Respiratory Distress Syndrome
- Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25− lymphocytes
- Sepsis leads to a reduced antigen‐specific primary antibody response
- Poly-microbial sepsis increases susceptibility to chronic viral infection and exacerbates CD8+ T cell exhaustion
- TNF and regulatory T cells are critical for sepsis‐induced suppression of T cells
- T cell pathways involving CTLA4 contribute to a model of acute lung injury
- Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
- Epstein-Barr virus reactivation in critically ill immunocompetent patients
- Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients
Cited by
- Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome
- Electroacupuncture at Zusanli (ST36), Guanyuan (CV4), and Qihai (CV6) Acupoints Regulates Immune Function in Patients with Sepsis via the PD-1 Pathway
- Herpes Zoster Reactivation Following COVID-19 and the Risk of Renal, Infectious, and Autoimmune Complications: A Global Propensity-Matched Cohort Study
- Why should lymphocytes immune profile matter in sepsis?
- Validation of reference genes for the normalization of the RT- qPCR in peripheral blood mononuclear cells of septic patients
- Advances in combined immunotherapy for sepsis
- Correlations of prognosis of severe purulent meningitis in children after rehabilitation with serum inflammatory cytokines, humoral immunity and the expression of TLR4 before and after treatment
- World Journal of Critical Care Medicine
- The CD4/CD8 ratio as an immune phenotype improves risk stratification for sepsis-associated acute kidney injury: A single-center, multi-ICU Chinese cohort study.
- Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework
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