Effects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage

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Summary

A series of short insertion mutations was introduced into the poliovirus gene for 3Dpol at a number of different locations, and when substituted for wild-type sequences in a full-length, infectious cDNA and tested for infectivity, all 3D mutants were nonviable.

Type
article
Published
1989-11-01
Cited by
55
References
52
Access
Open access

Keywords

Biology, RNA polymerase, Mutant, Polymerase, RNA-dependent RNA polymerase

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