Elongation activity of poliovirus RNA polymerase derived from Sabin type 1 sequence is not temperature sensitive.
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Summary
The contribution of Sabin 3Dpol sequences to the inability of the virus to grow at elevated temperatures must lie in a function or activity of the enzyme other than RNA polymerization.
- Type
- article
- Published
- 1995-08-01
- Cited by
- 4
- References
- 17
- OpenAlex
- https://openalex.org/W2121035905
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1588583
Keywords
Biology, Virology, Poliovirus, Elongation, Polymerase
References
- Nucleotide binding by the poliovirus RNA polymerase.
- A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice
- Synthesis of plus- and minus-strand RNA from poliovirion RNA template in vitro
- An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain
- Purification, characterization, and comparison of poliovirus RNA polymerase from native and recombinant sources.
- Mapping of mutations associated with neurovirulence in monkeys infected with Sabin 1 poliovirus revertants selected at high temperature
- Analysis of RNA synthesis of type 1 poliovirus by using an in vitro molecular genetic approach
- Effects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage
- Formation of poliovirus RNA polymerase 3D in Escherichia coli by cleavage of fusion proteins expressed from cloned viral cDNA.
- Properties and behavior of orally administered attenuated poliovirus vaccine.
- Reversion of the attenuated and temperature-sensitive phenotypes of the Sabin type 3 strain of poliovirus in vaccinees.
- The 5' noncoding region of the type 2 poliovirus vaccine strain contains determinants of attenuation and temperature sensitivity.
- Site-directed mutagenesis by overlap extension using the polymerase chain reaction.
- The molecular biology of poliovaccines.
- Enzymatic activity of poliovirus RNA polymerase synthesized in Escherichia coli from viral cDNA.
Cited by
- Studies on the attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg.
- Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein
- Vaccine-derived Mutation in Motif D of Poliovirus RNA-dependent RNA Polymerase Lowers Nucleotide Incorporation Fidelity*
- Poliovirus RNA-dependent RNA Vaccine-derived Mutation in Motif D of Enzymology:
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