Tetracycline Regulated Systems in Functional Oncogenomics
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Summary
The history and latest improvements in Tet-technology in the context of functional oncogenomics is reviewed and tetracycline regulated gene expression/ suppression systems developed and optimized by bioengineers over recent years are reviewed.
- Type
- article
- Published
- 2006-09-14
- Cited by
- 61
- References
- 1,104
- OpenAlex
- https://openalex.org/W1859237235
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15062799
Keywords
LNCaP, Androgen receptor, Transactivation, Sp1 transcription factor, Prostate cancer
References
- Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
- Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome
- Glomerular Mesangial Cell-specific Transactivation of Matrix Metalloproteinase 2 Transcription Is Mediated by YB-1*
- Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.
- Functions of a new family of sphingosine-1-phosphate receptors.
- Inhibition of progression to androgen‐independence by combined adjuvant treatment with antisense BCL‐XL and antisense Bcl‐2 oligonucleotides plus taxol after castration in the Shionogi tumor model
- The Hypereosinophilic Syndrome Associated with CD4+CD3″ Helper Type 2 (Th2) Lymphocytes
- Multiplexed microsphere-based flow cytometric assays.
- Ceramide in apoptosis: an overview and current perspectives.
- Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells.
- Applications and technical challenges of fluorescence in situ hybridization in stem cell research.
- Imatinib therapy for hypereosinophilic syndrome and eosinophilia-associated myeloproliferative disorders.
- Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary.
- Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors.
- Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the receptors Flt-1 and FLK-1 in benign, premalignant and malignant prostate tissues.
- Tetracycline-dependent gene regulation: combinations of transregulators yield a variety of expression windows.
- Clonality of isolated eosinophils in the hypereosinophilic syndrome.
- Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy.
- Tetracycline derivatives: alternative effectors for Tet transregulators.
- Metabolic Formation of Ceramide-1-Phosphate in Cerebellar Granule Cells: Evidence for the Phosphorylation of Ceramide by Different Metabolic Pathways
Cited by
- Expression of Y-box-binding protein YB-1 allows stratification into long- and short-term survivors of head and neck cancer patients
- Identification of Genes Involved in Hematopoietic Stem Cell Differentiation and Leukemia Differentiation and Leukemia
- Constitutive and functional expression of YB-1 in microglial cells.
- YB-1: Functional Analysis of a Potential Serum Marker for Neuroblastoma
- Liposomal short-chain C6 ceramide induces potent anti-osteosarcoma activity in vitro and in vivo.
- Tetraspanin 3 is Required for the Development and Propagation of Acute Myelogenous Leukemia
- Evaluation of YB-1 levels in patients with endometriosis.
- Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes
- SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.
- YBX1 expression and function in early hematopoiesis and leukemic cells
- Melanoma inhibitory activity promotes melanoma development through activation of YBX1
- YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.
- The p63 Protein Isoform ΔNp63α Modulates Y-box Binding Protein 1 in Its Subcellular Distribution and Regulation of Cell Survival and Motility Genes*
- Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo
- Discovery and validation of gene classifiers for endocrine-disrupting chemicals in zebrafish (danio rerio)
- Calcineurin-mediated YB-1 Dephosphorylation Regulates CCL5 Expression during Monocyte Differentiation*
- A transcriptomics-based biological framework for studying mechanisms of endocrine disruption in small fish species.
- YB‐1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma
- Molecular Decoy to the Y-Box Binding Protein-1 Suppresses the Growth of Breast and Prostate Cancer Cells whilst Sparing Normal Cell Viability
- K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling.
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