Selective integrin subunit reduction disrupts fibronectin extracellular matrix deposition and fibrillin 1 gene expression
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Summary
To investigate the role of integrins in fibrillin 1 ECM deposition, cells that normally produce and assemble fibrillillin 1 fibers in vitro were stably transfected with plasmid constructs encoding short interfering RNAs that target specific integrin subunits.
- Type
- article
- Published
- 2012-07-11
- Cited by
- 9
- References
- 53
- OpenAlex
- https://openalex.org/W2102514901
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16493266
Keywords
Fibronectin, Integrin, Extracellular matrix, Cell biology, Fibrillin
References
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- Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins
- Interactions of Fibrillin-1 with Heparin/Heparan Sulfate, Implications for Microfibrillar Assembly*
Cited by
- Epithelial–mesenchymal status influences how cells deposit fibrillin microfibrils
- Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis
- Development of conformation-sensitive probes to fibronectin for ECM targeting and imaging of fibrosis
- Quantitative protein profiling and pathway analysis of spinal arteriovenous malformations.
- Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins
- Proteomics reveals a set of highly enriched proteins in epiretinal membrane compared with inner limiting membrane.
- The genes regulating maintenance of cellular protein location are differentially expressed in porcine epithelial oviductal cells during longterm in vitro cultivation
- The role of extracelluar matrix in osteosarcoma progression and metastasis
- Endogenous Extracellular Matrix Regulates the Response of Osteosarcoma 3D Spheroids to Doxorubicin
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