Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications
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Summary
The goals of this review are to elucidate the role of K+ ions and K+ channels in the proliferation and apoptosis of PASMC, with an emphasis on abnormal cell growth in human and animal models of PAH, and to elaborate upon the targeting of K+.
- Type
- review
- Published
- 2008-03-01
- Cited by
- 131
- References
- 153
- Access
- Open access
- OpenAlex
- https://openalex.org/W1499833703
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22166529
Keywords
Apoptosis, Potassium channel, Cell biology, Depolarization, Programmed cell death
References
- Physiological Concentrations of K+ Inhibit Cytochrome c-dependent Formation of the Apoptosome*
- Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes.
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- Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone.
- A requirement for K+-channel activity in growth factor-mediated extracellular signal-regulated kinase activation in human myeloblastic leukemia ML-1 cells.
- Physiology of apoptosis.
- Apoptosis in the nervous system
- Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up‐regulation of PCNA in native contractile rat basilar artery smooth muscle
- Inhibition of Na+,K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+]i/[K+]i ratio.
- Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.
- Ionic Mechanism of Ouabain-Induced Concurrent Apoptosis and Necrosis in Individual Cultured Cortical Neurons
- Physiological roles and properties of potassium channels in arterial smooth muscle.
- Potassium currents in cultured human pulmonary arterial smooth muscle cells.
- Calcium sparks in smooth muscle.
- Bcl-2 family members and apoptosis, taken to heart.
- Inversion of the intracellular Na(+)/K(+) ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis.
- Effect of dexamethasone on voltage-gated K+ channels in Jurkat T-lymphocytes
- Calcium as a versatile second messenger in the control of gene expression
- Oncogenic potential of EAG K+ channels
- Primary pulmonary hypertension may be a heterogeneous disease with a second locus on chromosome 2q31.
Cited by
- Function of NADPH Oxidase 1 in Pulmonary Arterial Smooth Muscle Cells After Monocrotaline-Induced Pulmonary Vascular Remodeling
- Reverse the down regulation of miR-92b-3p by hypoxia can suppress the proliferation of pulmonary artery smooth muscle cells by targeting USP28.
- KCNQ potassium channels: new targets for pulmonary vasodilator drugs?
- 5-HT receptors and K(V) channel internalization.
- Non-invasive evaluation, therapy and transplantation in children with pulmonary arterial hypertension
- Nouveaux aspects cellulaires et moléculaires du remodelage vasculaire pulmonaire dans l’HTAP
- Activation of the phosphatidylinositol 3-kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation
- Smooth Muscle Cell Hypertrophy, Proliferation, Migration and Apoptosis in Pulmonary Hypertension
- Noradrenaline stimulates cell proliferation by suppressing potassium channels via Gi/o‐protein‐coupled α1B‐adrenoceptors in human osteoblasts
- New tricks for old dogs: KCNQ expression and role in smooth muscle
- The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2.
- The effects of siRNA against RPL22 on ET-1-induced proliferation of human pulmonary arterial smooth muscle cells.
- Involvement of large conductance Ca2+-activated K+ channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation
- Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery.
- Vascular Remodeling in Pulmonary Hypertension
- Contribution of voltage‐gated potassium channels to the regulation of apoptosis
- Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo
- Activation of cloned BKCa channels in nitric oxide-induced apoptosis of HEK293 cells
- High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BKCa channel
- Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats.
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