Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat
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Summary
The continued expression of activated caspase-3 and the persistence of cells with an apoptotic morphology for days after HI suggests a prolonged role for apoptosis in neonatal hypoxic ischemic brain injury.
- Type
- article
- Published
- 2000-11-01
- Cited by
- 429
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W1482301804
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9195278
Keywords
Nissl body, Apoptosis, Biology, Pathology, Programmed cell death
References
- Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
- Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain.
- Apoptosis in focal cerebral ischemia.
- Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.
- Apoptosis in the nervous system
- Glutamate induced cell death: apoptosis or necrosis?
- Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia
- Cell death: the significance of apoptosis.
- Neurology of the newborn.
- A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: morphological changes indicative of apoptosis.
- Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia.
- A system for characterizing cellular and molecular events in programmed neuronal cell death
- Experimental Biology of Cerebral Hypoxia-Ischemia: Relation to Perinatal Brain Damage
- Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats.
- Ultrastructural detection of DNA strand breaks in apoptotic neural cells by in situ end‐labelling techniques
- Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
- Susceptibility to apoptosis is enhanced in immature cortical neurons.
- Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury.
- Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.
- CPP32/Apopain Is a Key Interleukin 1 Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis (*)
Cited by
- Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?
- Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia.
- Transgenic expression of human FGF-1 protects against hypoxic-ischemic injury in perinatal brain by intervening at caspase-XIAP signaling cascades.
- Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.
- Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures
- The Protective Effect of Ischemic and Hypoxic Preconditioning on Hypoxic-ischemic Brain Injury in the Neonatal Rat: 1H Magnetic Resonance Spectroscopic Study
- HYPOXIC-ISCHEMIC BRAIN INJURY IN NEWBORN RAT : NEUROPROTECTIVE EFFECTS OF ACETAMINOPHEN AND THE INVOLVEMENT OF ACID SPHINGOMYELINASE ACTIVATION
- Effects of Neonatal Hypoxic Ischemic Brain Injury on Spatial Working Memory
- Estudio bioquímico y estructural de la muerte celular propia del desarrollo y la inducida por un evento hipóxico en el SNC durante el desarrollo
- Caspase inhibitors as anti-inflammatory and antiapoptotic agents.
- Behavioral and Neuroanatomical Consequences of Neonatal Hypoxic Ischemic Injury, and the Therapeutic Effects of Neuroprotectants: An Animal Model
- Pharmacological preconditioning with GYKI-52466: a prophylactic approach to neuroprotection against ischaemic stroke in the rat
- Mechanisms of ATF4-mediated neuronal apoptosis
- Magnetic Resonance Imaging of Hypoxic-Ischemic Brain Injury Development in the Newborn Rat
- Analysis of Manganese Enhanced MRI of the Normal and Injured Rat Central Nervous System
- Dopamine D1 and D2 Receptor Gene Expression and cGMP, IP3 and Ca2+ Regulation in the Brain Regions of Hypoxic Neonatal Rats: Role of Glucose, Oxygen and Epinephrine Supplementation
- Adrenergic and Glutamergic Receptor Gene Expression and Their Functional regulation in the Cerebral Cortex of Hypoxia Induced Neonatal Rats:Role of Oxygen,Epinephrine and Glucose Supplementation
- Neuronal death after perinatal cerebral hypoxia‐ischemia: Focus on autophagy—mediated cell death
- Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia–ischemia
- Inflammation and Cell Profileration Following Perinatal Brain Injury
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