Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1
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Summary
The findings demonstrate that CTLA-4 cosignaling is more complex than previously appreciated, with an ability to differentially regulate members of the MAPK family in T cells.
- Type
- article
- Published
- 2002-10-01
- Cited by
- 75
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W1672727064
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44716617
Keywords
MAPK/ERK pathway, Kinase, Cell biology, CD80, CD86
References
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- Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
- CTLA-4 regulates induction of anergy in vivo.
- The emerging role of CTLA-4 as an immune attenuator.
- Costimulatory regulation of T cell function.
- B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
- Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling*
- Molecular basis of T cell inactivation by CTLA-4.
- CD69‐triggered ERK activation and functions are negatively regulated by CD94 / NKG2‐A inhibitory receptor
- Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
- CTLA-4 Negative Signaling via Lipid Rafts: A New Perspective
- Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells
- Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF.
- CTLA-4 can function as a negative regulator of T cell activation.
- Upstream-downstream: CD28 cosignaling pathways and T cell function.
Cited by
- CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.
- RNA Interference of CTLA4 in Human Leukaemia T Cells
- Development and Characterization of a novel Immunotherapy against Prostate Cancer
- Targeting T Cells for the Immune-Modulation of Human Diseases
- CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation
- CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase1
- Charting protein complexes, signaling pathways, and networks in the immune system
- CD152 (CTLA-4) Determines CD4 T Cell Migration In Vitro and In Vivo
- Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions.
- TGF‐β: the perpetrator of immune suppression by regulatory T cells and suicidal T cells
- CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
- CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
- The reverse stop-signal model for CTLA4 function
- ICER/CREM‐mediated transcriptional attenuation of IL‐2 and its role in suppression by regulatory T cells
- Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
- Stereotactic radiosurgery and immunotherapy for metastatic spinal melanoma.
- Sepsis-Induced Potentiation of Peritoneal Macrophage Migration is mitigated by PD-1 Gene Deficiency
- Reversal of the TCR Stop Signal by CTLA-4
- CTLA-4 trafficking and surface expression
- The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
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