The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
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Summary
The T cell protein cytotoxic T lymphocyte antigen 4 (CTLA4) was identified as a crucial negative regulator of the immune system over 15 years ago, but its mechanisms of action are still under debate.
- Type
- review
- Published
- 2011-12-01
- Cited by
- 752
- References
- 159
- OpenAlex
- https://openalex.org/W2021009347
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9617595
Keywords
Cytotoxic T cell, Regulator, Cell biology, T cell, Immune system
References
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- CTLA-4 Differentially Regulates T Cell Responses to Endogenous Tissue Protein Versus Exogenous Immunogen1
- Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous.
- Re-establishing Peripheral Tolerance in the Absence of CTLA-4: Complementation by Wild-Type T Cells Points to an Indirect Role for CTLA-41
- Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
- A cellular calculus for signal integration by T cells
- CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.
- CD28 is required for germinal center formation.
- Structural Analysis of CTLA-4 Function In Vivo1
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
- Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
- Cutting Edge: A Soluble Form of CTLA-4 in Patients with Autoimmune Thyroid Disease
- Activation of human T cells with superantigen (staphylococcal enterotoxin B) and CD28 confers resistance to apoptosis via CD95.
- Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
- Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
- Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1
- TGF-β-Mediated Suppression by CD4+CD25+ T Cells Is Facilitated by CTLA-4 Signaling
- Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.
- Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
Cited by
- High viral burden restricts short-lived effector cell (SLEC) number at late times postinfection through increased nTreg expansion
- Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals
- Role of Fc–FcγR interactions in the antitumor activity of therapeutic antibodies
- Role of Interleukin 21 in CD4 T cell regulation
- Antigenicity of envelope protein complexes of Mycobacterium avium subsp. paratuberculosis and insights into T cell responses of infected animals
- Autologous human kidney proximal tubule epithelial cells (PTEC) modulate dendritic cell (DC), T cell and B cell responses
- The evolution of the autoantibody response in Graves' disease
- In vivo imaging of regulatory T cell mediated transplant tolerance
- ZAP-70, CTLA-4 and proximal T cell receptor signaling in cows infected with Mycobacterium avium subsp. paratuberculosis.
- From T cell "exhaustion" to anti-cancer immunity.
- The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment
- Understanding the CD28/CTLA‐4 (CD152) Pathway and Its Implications for Costimulatory Blockade
- CD28 costimulation: Walking the immunological tightrope
- The role of ICAM-1 mediated T cell:T cell interactions on CD8+ T cell effector function and differentiation
- The soluble isoform of CTLA‐4 as a regulator of T‐cell responses
- Cell‐extrinsic CTLA4‐mediated regulation of dendritic cell maturation depends on STAT3
- Inhibitory Receptors Beyond T Cell Exhaustion
- Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
- CD4+CD45RA−FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin‐secreting capacity in patients with type 1 diabetes
- The Promise of Preventive Cancer Vaccines
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