Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling*
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Summary
Results provide evidence for an alternate CD28-mediated signaling process involving Grb2 binding to the co-receptor, and indicate that both SH2 and SH3 domains contribute to CD28 binding.
- Type
- article
- Published
- 1998-01-02
- Cited by
- 142
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011444716
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46585357
Keywords
GRB2, SH2 domain, SH3 domain, Biology, Cell biology
References
- Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.
- Tight association of GRB2 with receptor protein‐tyrosine phosphatase alpha is mediated by the SH2 and C‐terminal SH3 domains.
- The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120
- Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.
- The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck
- The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
- Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase(*)
- Sphingomyelin‐ceramide turnover in CD28 costimulatory signaling
- The B7 and CD28 receptor families.
- The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
- Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
- Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK (*)
- Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
- Involvement of Src-homology-2-domain-containing protein-tyrosine phosphatase 2 in T cell activation.
- CD28 signals through acidic sphingomyelinase
- C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
- Activation of src family kinase lck following CD28 crosslinking in the Jurkat leukemic cell line.
- T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras
- CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
- B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
Cited by
- ICOS and CD28: similar or separate costimulators of T cells?
- Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction*
- CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation.
- Proline-rich sequence recognition domains (PRD): ligands, function and inhibition.
- Lenalidomide targets the T-cell co-stimulatory pathway to mediate immune modulation
- On adaptor proteins shaping Ca 2+ signals in activated B lymphocytes
- A point mutation in CD28 distinguishes proliferative signals from survival signals
- Phosphodiesterases as targets for modulating T-cell responses.
- The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
- Molecular regulation of cytoskeletal rearrangements during T cell signalling.
- B Cell Antigen Receptor-intrinsic Costimulation of IgG and IgE Isotypes
- TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway.
- Grb2 and Gads Exhibit Different Interactions with CD28 and Play Distinct Roles in CD28-Mediated Costimulation1
- Role of Grb2 in growth and differentiation of embryonic stem cells
- CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation
- Regulation of effector/memory T cell activation by inducible co-stimulator (ICOS).
- Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1
- GRID: A Novel Grb-2-Related Adapter Protein That Interacts with the Activated T Cell Costimulatory Receptor CD28
- Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo1
- Activation of c-Jun N-Terminal Kinase and Activator Protein 1 by Receptor Activator of Nuclear Factor κB
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- Epidermal Growth Factor Induces Coupling of Protein-tyrosine Phosphatase 1D to GRB2 via the COOH-terminal SH3 Domain of GRB2*
- The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
- Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins.
- The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to rats signaling
- Signaling through Grb2/Ash-control of the Ras pathway and cytoskeleton.